Assessment of cardiovascular disease risk factors in a genetically homogenous population of Parsi Zoroastrians in the United States: A pilot study

Itzel Vazquez-Vidal, Geetha Chittoor, Sandra Laston, Sobha Puppala, Zeeba Kayani, Kaizeen Mody, Anthony G. Comuzzie, Shelley A. Cole, V. Saroja Voruganti

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: Genetically isolated and homogenous populations are ideal for detecting genes underlying common complex diseases. The use of isolated populations with reduced disease heterogeneity has led to significant gene discoveries in the past. The aim of this pilot study was to assess the prevalence of cardiovascular disease (CVD) risk phenotypes in a genetically homogenous population of Parsi Zoroastrians in the United States. Methods: Anthropometrics, blood pressure, and medical history were collected from 152 men and 186 women participating in a pilot study as part of the Parsi Family Study. The relative pairs used in the study included 60 parent-off springs, 28 siblings, 6 grandparent-grandchild, 7 avuncular, 18 half-siblings, 7 half-avuncular, and one half-first cousin. Estimates of genetic and environmental influence were calculated using a maximum likelihood-based variance components method implemented in SOLAR. Results: The prevalence of overweight/obesity in adults (62%) was on par with current US prevalence. Hypertension and prehypertension were prevalent in 16% and 46% of the participants, respectively. The quantitative genetic analysis revealed significant heritabilities for all anthropometric phenotypes (PG=-0.88, P

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalAmerican Journal of Human Biology
Volume28
Issue number3
DOIs
StatePublished - May 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Anthropology
  • Anatomy
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

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