Assessing Symptom Burden in Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Patients

Juan Garza, Jane Margret Anderson, Robyn M. Scherber

Research output: Contribution to journalReview articlepeer-review

Abstract

Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes are rare types of chronic myeloid hematologic neoplasms. Patients with overlap syndrome have similar clinical features, mutations, and disease course, to other chronic myeloid malignancies. Limited data also suggests that overlap syndromes patients experience long standing and at times poorly controlled symptoms that may be underrecognized. In this article, we discuss the etiologies of symptoms in patients with overlap syndromes and currently available symptom burden assessment tools. Overall, symptom burden is an important consideration in patients with overlap syndrome, and efforts are ongoing to further investigate symptom burden and quality of life in this population.

Original languageEnglish (US)
Pages (from-to)475-489
Number of pages15
JournalHematology/Oncology Clinics of North America
Volume34
Issue number2
DOIs
StatePublished - Apr 2020
Externally publishedYes

Keywords

  • Atypical chronic myelogenous leukemia
  • Chronic myelomonocytic leukemia
  • Chronic neutrophilic leukemia
  • Juvenile myelomonocytic leukemia
  • Quality of life
  • Symptom burden

ASJC Scopus subject areas

  • Hematology
  • Oncology

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