TY - JOUR
T1 - Assessing effects of long-term food restriction on myocardial energetics in the isolated heart preparation
AU - Klebanov, Simon
AU - Herlihy, Jeremiah T.
AU - Freeman, Gregory L.
N1 - Funding Information:
We would like to thank Emilio Garcia and Danny Escobedo for their excellent technical support. This work was supported by grants AG011088, T32AG00205 and K07-AG00469 from the National Institute of Aging and by the Research Service of the Department of Veterans Affairs.
PY - 2002/7
Y1 - 2002/7
N2 - Food restriction (FR) may increase longevity by increasing the efficiency of energy utilization by some organs. We tested whether any effect of FR on the energy efficiency of isolated, isovolumically beating hearts could be observed, by studying four groups of rats: (1) AL fed (AL) 10-13-month-old rats, (2) age matched, FR at 60% of AL rats, (3) young AL, heart weight matched to FR rats and (4) 10-13-month-old AL rats, short-term FR for the last 3 weeks of life. The oxygen cost of tension development was not different among the groups. With contractility changed by calcium, the oxygen cost of contractility was higher in the young AL than in the adult rats either AL or short-term FR. With isoproterenol, it was higher in FR than in AL groups. The basal metabolic rate of hearts was higher in the adult AL than in the short-term, but not long-term, FR rats. In the long run, FR did not significantly change the pattern of cardiac energy utilization of isolated, isovolumically beating hearts. Our observations do not lend support to the hypothesis that the anti-aging action of FR is mediated by changes in cardiac efficiency.
AB - Food restriction (FR) may increase longevity by increasing the efficiency of energy utilization by some organs. We tested whether any effect of FR on the energy efficiency of isolated, isovolumically beating hearts could be observed, by studying four groups of rats: (1) AL fed (AL) 10-13-month-old rats, (2) age matched, FR at 60% of AL rats, (3) young AL, heart weight matched to FR rats and (4) 10-13-month-old AL rats, short-term FR for the last 3 weeks of life. The oxygen cost of tension development was not different among the groups. With contractility changed by calcium, the oxygen cost of contractility was higher in the young AL than in the adult rats either AL or short-term FR. With isoproterenol, it was higher in FR than in AL groups. The basal metabolic rate of hearts was higher in the adult AL than in the short-term, but not long-term, FR rats. In the long run, FR did not significantly change the pattern of cardiac energy utilization of isolated, isovolumically beating hearts. Our observations do not lend support to the hypothesis that the anti-aging action of FR is mediated by changes in cardiac efficiency.
KW - Caloric restriction
KW - Cardiac efficiency
KW - Cardiac metabolism
KW - Contractility
KW - Food restriction
KW - Isolated heart
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U2 - 10.1016/S0047-6374(02)00078-7
DO - 10.1016/S0047-6374(02)00078-7
M3 - Article
C2 - 12297340
AN - SCOPUS:0036629791
SN - 0047-6374
VL - 123
SP - 1375
EP - 1388
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 10
ER -