Assessing declarative memory in schizophrenia using Wisconsin card sorting test stimuli: The paired associate recognition test

J. Daniel Ragland, David M. Censits, Ruben C. Gur, David C. Glahn, Fiona Gallacher, Raquel E. Gur

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The Paired Associate Recognition Test (PART) was developed to measure declarative memory using Wisconsin Card Sorting Test (WCST) stimuli, so that both tasks could be administered during functional neuroimaging to differentiate memory and executive function, and associated frontal and temporal lobe activation in schizophrenia. The current study was designed to compare PART and WCST performance in schizophrenic patients and to examine effects of medication and symptomatology. The PART, WCST, and standard declarative memory tasks were administered to 30 chronic schizophrenic patients and 30 matched healthy control subjects. Supporting task validity was the finding that patients were equally impaired on the PART and the WCST. Neuroleptics did not appear to affect performance. The effect of anticholinergic medication correlated negatively with WCST performance in a small subsample. Severity of schizophrenia-specific symptoms measured at intake on the Brief Psychiatric Rating Scale correlated negatively with performance on the WCST. These results support the application of the PART and WCST in future functional neuroimaging studies.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalPsychiatry Research
Volume60
Issue number2-3
DOIs
StatePublished - Mar 29 1996
Externally publishedYes

Keywords

  • Anticholinergic effects
  • Neuroleptic effects
  • Neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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