Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection

S. C. Harris, J. E. Wallace, G. Foulds, M. G. Rinaldi

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 μg/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

Original languageEnglish (US)
Pages (from-to)714-716
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume33
Issue number5
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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