Aspirin and folate binding: In vivo and in vitro studies of serum binding and urinary excretion of endogenous folate

V. A. Lawrence, J. E. Loewenstein, E. R. Eichner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To clarify the effect of aspirin and folate balance, we studied serum concentration, protein binding, and urinary excretion of endogenous folate. A healthy woman twice followed an 11-day protocol of constant diet, blood sampling twice daily, collection of all urine, and 650 mg of aspirin by mouth every 4 hours on the middle 3 days. As determined by equilibrium dialysis and Lactobacillus casei assay, aspirin induced a brisk, significant but reversible fall in total and bound serum folate and a small but insignificant rise in urinary folate excretion. Aspirin in vitro also displaced significant amounts of bound serum folate. Thus, aspirin in therapeutic doses can contribute to subnormal serum folate values, and if it increases urinary folate excretion even slightly, may impair folate balance.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalJournal of Laboratory and Clinical Medicine
Volume103
Issue number6
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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