TY - JOUR
T1 - Aspirin and folate binding
T2 - In vivo and in vitro studies of serum binding and urinary excretion of endogenous folate
AU - Lawrence, V. A.
AU - Loewenstein, J. E.
AU - Eichner, E. R.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - To clarify the effect of aspirin and folate balance, we studied serum concentration, protein binding, and urinary excretion of endogenous folate. A healthy woman twice followed an 11-day protocol of constant diet, blood sampling twice daily, collection of all urine, and 650 mg of aspirin by mouth every 4 hours on the middle 3 days. As determined by equilibrium dialysis and Lactobacillus casei assay, aspirin induced a brisk, significant but reversible fall in total and bound serum folate and a small but insignificant rise in urinary folate excretion. Aspirin in vitro also displaced significant amounts of bound serum folate. Thus, aspirin in therapeutic doses can contribute to subnormal serum folate values, and if it increases urinary folate excretion even slightly, may impair folate balance.
AB - To clarify the effect of aspirin and folate balance, we studied serum concentration, protein binding, and urinary excretion of endogenous folate. A healthy woman twice followed an 11-day protocol of constant diet, blood sampling twice daily, collection of all urine, and 650 mg of aspirin by mouth every 4 hours on the middle 3 days. As determined by equilibrium dialysis and Lactobacillus casei assay, aspirin induced a brisk, significant but reversible fall in total and bound serum folate and a small but insignificant rise in urinary folate excretion. Aspirin in vitro also displaced significant amounts of bound serum folate. Thus, aspirin in therapeutic doses can contribute to subnormal serum folate values, and if it increases urinary folate excretion even slightly, may impair folate balance.
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M3 - Article
C2 - 6726059
AN - SCOPUS:0021268132
VL - 103
SP - 944
EP - 948
JO - Translational Research
JF - Translational Research
SN - 1931-5244
IS - 6
ER -