TY - JOUR
T1 - Aspergillus antigen detection in the diagnosis of invasive aspergillosis
AU - Patterson, Thomas F.
AU - Miniter, Peggy
AU - Patterson, Jan Evans
AU - Rappeport, Joel M.
AU - Andriole, Vincent T.
PY - 1995/6
Y1 - 1995/6
N2 - The utility of serum Aspergillus antigen in invasive aspergillosis was determined by identifying patients with =50 ng/mL Aspergillus carbohydrate antigen by ELISA. Patients were identified from a university hospital over a 65-month period. Nineteen patients with antigenemia had proven invasive aspergillosis, 16 had probable invasive aspergillosis, and 14 had an indeterminate diagnosis. There were 5 patients with false-positive results. Antigen levels were higher in disseminated infection than in invasive pulmonary aspergillosis (median levels, 500 and 121 ng/mL, respectively). Survival also correlated with antigenemia. Serial samples were obtained from 31 of 35 patients with proven or probable invasive aspergillosis. Fifteen of 19 patients with rising or persistent antigenemia died, whereas only 1 of 12 patients who cleared antigenemia died. Higher antigen levels were useful in predicting disseminated disease, and the course of antigenemia correlated with clinical outcome. Antigen detection may be a useful addition in the management of invasive aspergillosis.
AB - The utility of serum Aspergillus antigen in invasive aspergillosis was determined by identifying patients with =50 ng/mL Aspergillus carbohydrate antigen by ELISA. Patients were identified from a university hospital over a 65-month period. Nineteen patients with antigenemia had proven invasive aspergillosis, 16 had probable invasive aspergillosis, and 14 had an indeterminate diagnosis. There were 5 patients with false-positive results. Antigen levels were higher in disseminated infection than in invasive pulmonary aspergillosis (median levels, 500 and 121 ng/mL, respectively). Survival also correlated with antigenemia. Serial samples were obtained from 31 of 35 patients with proven or probable invasive aspergillosis. Fifteen of 19 patients with rising or persistent antigenemia died, whereas only 1 of 12 patients who cleared antigenemia died. Higher antigen levels were useful in predicting disseminated disease, and the course of antigenemia correlated with clinical outcome. Antigen detection may be a useful addition in the management of invasive aspergillosis.
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U2 - 10.1093/infdis/171.6.1553
DO - 10.1093/infdis/171.6.1553
M3 - Article
C2 - 7769291
AN - SCOPUS:0029027142
SN - 0022-1899
VL - 171
SP - 1553
EP - 1558
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -