Aspergillus antigen detection in bronchoalveolar lavage fluid from patients with invasive aspergillosis and aspergillomas

Charles P. Andrews, Marc H Weiner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Improved diagnostic techniques have been needed for pulmonary aspergillosis, a common opportunistic fungal infection with a high mortality rate. Radioimmunoassay was used in this study to detect Aspergillus antigen in bronchoalveolar lavage fluid. In four patients with invasive aspergillosis or aspergillomas, Aspergillus antigen was detected in bronchoalveolar lavage fluid. In two patients, results of fungal cultures were negative or delayed. The specificity of antigen detection in bronchoalveolar lavage fluid was 91 percent in 35 control patients with a variety of pulmonary disorders. The technique of radioimmunoassay detection of microbial antigen in bronchoalveolar lavage fluid appears promising for the diagnosis of aspergillosis.

Original languageEnglish (US)
Pages (from-to)328-334
Number of pages7
JournalThe American journal of medicine
Volume73
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Aspergillosis
Bronchoalveolar Lavage Fluid
Aspergillus
Antigens
Radioimmunoassay
Pulmonary Aspergillosis
Mycoses
Opportunistic Infections
Lung
Mortality

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Aspergillus antigen detection in bronchoalveolar lavage fluid from patients with invasive aspergillosis and aspergillomas. / Andrews, Charles P.; Weiner, Marc H.

In: The American journal of medicine, Vol. 73, No. 3, 1982, p. 328-334.

Research output: Contribution to journalArticle

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