Asking the age-old questions

Research output: Contribution to journalShort survey

9 Scopus citations

Abstract

Control of lifespan in Caenorhabditis elegans by the DAF-2 insulin-like signaling pathway requires daf-16, which encodes a member of the forkhead family of transcription factors. A new study provides evidence that DAF-2 negatively regulates DAF-16 activity by promoting its retention in the cytoplasm. But, constitutive targeting of DAF-16 to the nucleus is not sufficient to extend lifespan, revealing a new layer of complexity in the genetic control of aging in the nematode.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalNature Genetics
Volume28
Issue number2
DOIs
StatePublished - Jun 26 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Asking the age-old questions'. Together they form a unique fingerprint.

  • Cite this