Asking the age-old questions

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations


Control of lifespan in Caenorhabditis elegans by the DAF-2 insulin-like signaling pathway requires daf-16, which encodes a member of the forkhead family of transcription factors. A new study provides evidence that DAF-2 negatively regulates DAF-16 activity by promoting its retention in the cytoplasm. But, constitutive targeting of DAF-16 to the nucleus is not sufficient to extend lifespan, revealing a new layer of complexity in the genetic control of aging in the nematode.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalNature Genetics
Issue number2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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