Asking the age-old questions

P. L. Larsen

doi:10.1038/88797

Asking the age-old questions

P. L. Larsen

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Control of lifespan in Caenorhabditis elegans by the DAF-2 insulin-like signaling pathway requires daf-16, which encodes a member of the forkhead family of transcription factors. A new study provides evidence that DAF-2 negatively regulates DAF-16 activity by promoting its retention in the cytoplasm. But, constitutive targeting of DAF-16 to the nucleus is not sufficient to extend lifespan, revealing a new layer of complexity in the genetic control of aging in the nematode.

Original language	English (US)
Pages (from-to)	102-104
Number of pages	3
Journal	Nature Genetics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1038/88797
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/88797

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Asking the age-old questions

Abstract

ASJC Scopus subject areas

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