Arterial injury repair in nonhuman primates - The role of PDGF receptor-β

Michael J. Englesbe, Mark G. Davies, Suzanne M. Hawkins, Patrick C.H. Hsieh, Günter Daum, Richard D. Kenagy, Alexander W. Clowes

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background This study documents the time course of the response to injury of the saphenous artery in baboons and the role of the platelet-derived growth factor-β. Fundamental differences with the well-characterized rat arterial injury model have been found. Materials and methods Thirty-eight baboons received a unilateral balloon injury to the saphenous artery and were treated with a chimeric blocking antibody to PDGFR-β or vehicle control for 7, 14, or 28 days. The arteries were evaluated morphologically and for cell proliferation. Results Both medial and intimal smooth muscle cell proliferation were elevated 7 days after injury and were back close to baseline at 14 days. Unlike the rat, blockade of PDGFR-β inhibited medial proliferation over 80% at 7 and 14 days, while intimal proliferation was only inhibited at 14 days (>95%). Also, unlike the rat, the baboon arterial media, as well as the intima, increased in size by 14 days after injury. Blockade of PDGFR-β completely inhibited both intimal and medial growth at 14 days, but there was less of an effect on intimal growth at 28 days. Conclusion Blockade of PDGFR-β may be a clinical approach to inhibit intimal hyperplasia in humans, but this study raises concerns about the long-term efficacy of this treatment.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalJournal of Surgical Research
Volume119
Issue number1
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Keywords

  • arterial injury
  • intimal hyperplasia
  • nonhuman primate
  • PDGFR-β
  • vascular injury

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Englesbe, M. J., Davies, M. G., Hawkins, S. M., Hsieh, P. C. H., Daum, G., Kenagy, R. D., & Clowes, A. W. (2004). Arterial injury repair in nonhuman primates - The role of PDGF receptor-β. Journal of Surgical Research, 119(1), 80-84. https://doi.org/10.1016/j.jss.2003.10.015