Arsenic trioxide: An anti cancer missile with multiple warheads

Yair Gazitt, Cagla Akay

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

The proven efficacy of ATO in the treatment of APL and the emerging importance of ATO in other diseases prompted extensive studies of the mechanisms of action of ATO in APL and in other types of cancers. In this review we will focus on downstream events in ATO-induced intrinsic and extrinsic apoptotic pathways with an emphasis on the role of pro-apoptotic and anti-apoptotic proteins and the role of p53 in ATO-induced apoptosis including its effect on cell cycle, its anti-mitotic effect and the role of apoptosis inducing factors (AIF) in ATO-induced apoptosis, chromatin condensation and nuclear fragmentation in myeloma cells as a model.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalHematology
Volume10
Issue number3
DOIs
StatePublished - Jun 2005

Keywords

  • AIF
  • Apoptosis
  • Arsenic trioxide
  • BID
  • p53
  • TRAIL

ASJC Scopus subject areas

  • Hematology

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