Arrogant: An application to manipulate large gene collections

Amit V. Kulkarni, Noelle Sevilir Williams, Yun Lian, Jonathan D. Wren, David Mittelman, Alexander Pertsemlidis, Harold R. Garner

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Summary: ARROGANT (ARRay OrGANizing Tool) is a software tool developed to facilitate the identification, annotation and comparison of large collections of genes or clones. The objective is to enable users to compile gene/clone collections from different databases, allowing them to design experiments and analyze the collections as well as associated experimental data efficiently. ARROGANT can relate different sequence identifiers to their common reference sequence using the UniGene database, allowing for the comparison of data from two different microarray experiments. ARROGANT has been successfully used to analyze microarray expression data for colon cancer, to compile genes potentially related to cardiac diseases for subsequent resequencing (to identify single nucleotide polymorphisms, SNPs), to design a new comprehensive human cDNA microarray for cancer, to combine and compare expression data generated by different microarrays and to provide annotation for genes on custom and Affymetrix chips.

Original languageEnglish (US)
Pages (from-to)1410-1417
Number of pages8
JournalBioinformatics
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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  • Cite this

    Kulkarni, A. V., Williams, N. S., Lian, Y., Wren, J. D., Mittelman, D., Pertsemlidis, A., & Garner, H. R. (2002). Arrogant: An application to manipulate large gene collections. Bioinformatics, 18(11), 1410-1417. https://doi.org/10.1093/bioinformatics/18.11.1410