Are endogenous retroviruses involved in human autoimmune disease?

Norman Talal, Eliezer Flescher, Howard Dang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A role for viruses in the etiopathogenesis of human autoimmune diseases has long been suspected but has not yet been proven. In Sjögren's syndrome (SS), there is continuing experimental support for the possible involvement of Epstein-Barr virus. Since the advent of AIDS, there is also great interest in retroviruses and autoimmune disease. We previously reported that 30% of SS patients and 36% of systemic lupus erythematosus (SLE) patients have serum antibodies to the p24 gag protein of HIV-1. We now report that two mechanisms classic for retroviruses (molecular mimicry and immunosuppression) may be operative in SS and SLE. The p24 gag protein shares a proline-rich epitope with the Sm nucleoprotein to which many SLE patients have antibodies. The impaired lymphocyte activation seen in peripheral blood T cells in SS patients is also seen in a human T cell line infected with an A-type retroviral particle linked to SS. Many studies suggest that endogenous retroviral sequences are important in immuno-regulation. We now suggest that endogenous retroviral sequences may also be important in the etiology and pathogenesis of SS and SLE.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalJournal of Autoimmunity
Volume5
Issue numberSUPPL. A
DOIs
StatePublished - 1992

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Endogenous Retroviruses
Autoimmune Diseases
Systemic Lupus Erythematosus
gag Gene Products
Retroviridae
Molecular Mimicry
T-Lymphocytes
Nucleoproteins
Antibodies
Lymphocyte Activation
Human Herpesvirus 4
Proline
Immunosuppression
HIV-1
Epitopes
Blood Cells
Acquired Immunodeficiency Syndrome
Viruses
Cell Line
Serum

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Are endogenous retroviruses involved in human autoimmune disease? / Talal, Norman; Flescher, Eliezer; Dang, Howard.

In: Journal of Autoimmunity, Vol. 5, No. SUPPL. A, 1992, p. 61-66.

Research output: Contribution to journalArticle

Talal, Norman ; Flescher, Eliezer ; Dang, Howard. / Are endogenous retroviruses involved in human autoimmune disease?. In: Journal of Autoimmunity. 1992 ; Vol. 5, No. SUPPL. A. pp. 61-66.
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