Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy

Sreeram Kalarical Janardhanan, Shoba Narayan, Gopal Abbineni, Andrew Hayhurst, Chuanbin Mao

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Filamentous M13 phage can be engineered to display cancer cell-targeting or tumor-homing peptides through phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer drugs to deliver them to the cancer cells. We studied the evolution of structures of the complexes between anionic filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric photosensitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and liposomes are interwoven into a "nanoweb." The chemical and biological properties of the phage-liposome nanoweb were evaluated for possible application in drug delivery. This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells.

Original languageEnglish (US)
Pages (from-to)2524-2535
Number of pages12
JournalMolecular cancer therapeutics
Volume9
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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