Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy

Sreeram Kalarical Janardhanan, Shoba Narayan, Gopal Abbineni, Andrew Hayhurst, Chuanbin Mao

    Research output: Contribution to journalArticle

    26 Scopus citations

    Abstract

    Filamentous M13 phage can be engineered to display cancer cell-targeting or tumor-homing peptides through phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer drugs to deliver them to the cancer cells. We studied the evolution of structures of the complexes between anionic filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric photosensitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and liposomes are interwoven into a "nanoweb." The chemical and biological properties of the phage-liposome nanoweb were evaluated for possible application in drug delivery. This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells.

    Original languageEnglish (US)
    Pages (from-to)2524-2535
    Number of pages12
    JournalMolecular cancer therapeutics
    Volume9
    Issue number9
    DOIs
    StatePublished - Sep 2010

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Fingerprint Dive into the research topics of 'Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy'. Together they form a unique fingerprint.

  • Cite this