Arboviral encephalitides: Transmission, emergence, and pathogenesis

Bradley S. Hollidge, Francisco González-Scarano, Samantha S. Soldan

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Arthropod-borne viruses (arboviruses) are of paramount concern as a group of pathogens at the forefront of emerging and re-emerging diseases. Although some arboviral infections are asymptomatic or present with a mild influenza-like illness, many are important human and veterinary pathogens causing serious illness ranging from rash and arthritis to encephalitis and hemorrhagic fever. Here, we discuss arboviruses from diverse families (Flaviviruses, Alphaviruses, and the Bunyaviridae) that are causative agents of encephalitis in humans. An understanding of the natural history of these infections as well as shared mechanisms of neuroinvasion and neurovirulence is critical to control the spread of these viruses and for the development of effective vaccines and treatment modalities.

Original languageEnglish (US)
Pages (from-to)428-442
Number of pages15
JournalJournal of Neuroimmune Pharmacology
Issue number3
StatePublished - Sep 2010


  • Alphavirus
  • Bunyaviridae
  • Flavivirus
  • arbovirus
  • encephalitis

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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