Aquatic light/dark plus maze novel environment for assessing anxious versus exploratory behavior in zebrafish (Danio rerio) and other small teleost fish

Georgianna G. Gould

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Initial introduction into novel environments produces in zebrafish behaviors consistent with predator evasion, fear, and/or anxiety. This protocol is for a light/dark plus maze novel environment test utilizing two elements of those behavioral responses, thigmotaxis and light avoidance, to assess "anxiety states" in zebrafish. The test is based upon the rodent elevated plus maze and is scored similarly, except for fish white arms replace opened arms, and black arms parallel closed arms. Several pharmaceuticals that reduce anxiety levels in patients and increase open arm exploration by rodents in the elevated plus maze also increase zebrafish entries into and time spent in white arms of the maze.

Original languageEnglish (US)
Title of host publicationZebrafish Neurobehavioral Protocols
EditorsAllan Kalueff, Jonathan Cachat
Pages99-108
Number of pages10
DOIs
StatePublished - Jan 1 2011

Publication series

NameNeuromethods
Volume51
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Novel environment
  • anxiety
  • exploration
  • light avoidance
  • light/dark plus maze
  • thigmotaxis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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