Appraising contemporary strategies to combat multidrug resistant gram-negative bacterial infections-proceedings and data from the gram-negative resistance summit

Marin H. Kollef, Yoav Golan, Scott T. Micek, Andrew F. Shorr, Marcos I. Restrepo

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The emerging problem of antibiotic resistance, especially among Gram-negative bacteria (GNB), has become a serious threat to global public health. Very few new antibacterial classes with activity against antibiotic-resistant GNB have been brought to market. Renewed and growing attention to the development of novel compounds targeting antibiotic-resistant GNB, as well as a better understanding of strategies aimed at preventing the spread of resistant bacterial strains and preserving the efficacy of existing antibiotic agents, has occurred. The Gram-Negative Resistance Summit convened national opinion leaders for the purpose of analyzing current literature, epidemiologic trends, clinical trial data, therapeutic options, and treatment guidelines related to the management of antibiotic-resistant GNB infections. After an in-depth analysis, the Summit investigators were surveyed with regard to 4 clinical practice statements. The results then were compared with the same survey completed by 138 infectious disease and critical care physicians and are the basis of this article.

Original languageEnglish (US)
Pages (from-to)S33-S55
JournalClinical Infectious Diseases
Volume53
Issue numberSUPPL. 2
DOIs
StatePublished - Sep 15 2011

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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