Applications of miRNA technology for atherosclerosis

Hiroe Toba; Dolores Cortez; Merry L. Lindsey; Robert J. Chilton

doi:10.1007/s11883-013-0386-9

Applications of miRNA technology for atherosclerosis

Hiroe Toba, Dolores Cortez, Merry L. Lindsey, Robert J. Chilton

Division of Cardiology

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

Original language	English (US)
Article number	386
Journal	Current atherosclerosis reports
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/s11883-013-0386-9
State	Published - Feb 2014

Keywords

Atherosclerosis
Cardiovascular disease
Diabetes
Hyperlipidemia
Insulin resistance
Matrix metalloproteinase
Metabolics
MicroRNA
Obesity
Proteomics

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11883-013-0386-9

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title = "Applications of miRNA technology for atherosclerosis",

abstract = "MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.",

keywords = "Atherosclerosis, Cardiovascular disease, Diabetes, Hyperlipidemia, Insulin resistance, Matrix metalloproteinase, Metabolics, MicroRNA, Obesity, Proteomics",

author = "Hiroe Toba and Dolores Cortez and Lindsey, {Merry L.} and Chilton, {Robert J.}",

note = "Funding Information: We acknowledge funding support from the National Institutes of Health NHLBI HHSN 268201000036C (N01-HV-00244) for the San Antonio Cardiovascular Proteomics Center, HL075360 and HL051971, and the Veteran{\textquoteright}s Administration (Merit) to MLL. ",

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AU - Cortez, Dolores

AU - Lindsey, Merry L.

AU - Chilton, Robert J.

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KW - Atherosclerosis

KW - Cardiovascular disease

KW - Diabetes

KW - Hyperlipidemia

KW - Insulin resistance

KW - Matrix metalloproteinase

KW - Metabolics

KW - MicroRNA

KW - Obesity

KW - Proteomics

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Applications of miRNA technology for atherosclerosis

Abstract

Keywords

ASJC Scopus subject areas

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