Application of immunohistochemistry in the diagnosis of pulmonary and pleural neoplasms

Jennifer S. Woo, Opal L. Reddy, Matthew Koo, Yan Xiong, Faqian Li, Haodong Xu

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Context.-A vast majority of neoplasms arising from lung or pleura are initially diagnosed based on the histologic evaluation of small transbronchial, endobronchial, or needle core biopsies. Although most diagnoses can be determined by morphology alone, immunohistochemistry can be a valuable diagnostic tool in the workup of problematic cases. Objective.-To provide a practical approach in the interpretation and immunohistochemical selection of lung/ pleura-based neoplasms obtained from small biopsy samples. Data Sources.-A literature review of previously published articles and the personal experience of the authors were used in this review article. Conclusion.-Immunohistochemistry is a useful diagnostic tool in the workup of small biopsies from the lung and pleura sampled by small biopsy techniques.

Original languageEnglish (US)
Pages (from-to)1195-1213
Number of pages19
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - Sep 2017
Externally publishedYes

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Pathology and Forensic Medicine


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