Application of an independent dose calculation software for estimating the impact of inter-fractional setup shifts in Helical Tomotherapy treatments

Erik Dzintars, Nikos Papanikolaou, Panayiotis Mavroidis, Amir Sadeghi, Sotirios Stathakis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of this study is to validate the capability of in-house independent point dose calculation software to be used as a second check for Helical Tomotherapy treatment plans. The software performed its calculations in homogenous conditions (using the Cheese phantom, which is a cylindrical phantom with radius 15cm and length 18cm) using a factor-based algorithm. Fifty patients, who were treated for pelvic (10), prostate (14), lung (10), head & neck (12) and brain (4) cancers, were used. Based on the individual patient kVCT images and the pretreatment MVCT images for each treatment fraction, the corresponding daily patient setup shifts in the IEC-X, IEC-Y, and IEC-Z directions were registered. For each patient, the registered fractional setup shifts were grouped into systematic and random shifts. The average systematic dosimetric variations showed small dose deviation for the different cancer types (1.0%-3.0%) compared to the planned dose. Of the fifty patients, only three had percent differences larger than 5%. The average random dosimetric variations showed relatively small dose deviations (0.2%-1.1%) compared to the planned dose. None of the patients had percent differences larger than 5%. By examining the individual fractions of each patient, it is observed that only in 31 out of 1358 fractions the percent differences exceeded the border of 5%. These results indicate that the overall dosimetric impact from systematic and random variations is small and that the software is a capable platform for independent point dose validation for the Helical Tomotherapy modality.

Original languageEnglish (US)
Pages (from-to)615-623
Number of pages9
JournalPhysica Medica
Volume29
Issue number6
DOIs
StatePublished - Nov 2013

Fingerprint

Intensity-Modulated Radiotherapy
estimating
Software
computer programs
dosage
shift
Therapeutics
cancer
deviation
Cheese
borders
Brain Neoplasms
pretreatment
lungs
brain
Prostate
Neck
platforms
Head
Lung

Keywords

  • Helical Tomotherapy
  • Independent point dose calculation
  • Inter-fractional shifts
  • Patient setup

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

Application of an independent dose calculation software for estimating the impact of inter-fractional setup shifts in Helical Tomotherapy treatments. / Dzintars, Erik; Papanikolaou, Nikos; Mavroidis, Panayiotis; Sadeghi, Amir; Stathakis, Sotirios.

In: Physica Medica, Vol. 29, No. 6, 11.2013, p. 615-623.

Research output: Contribution to journalArticle

Dzintars, Erik ; Papanikolaou, Nikos ; Mavroidis, Panayiotis ; Sadeghi, Amir ; Stathakis, Sotirios. / Application of an independent dose calculation software for estimating the impact of inter-fractional setup shifts in Helical Tomotherapy treatments. In: Physica Medica. 2013 ; Vol. 29, No. 6. pp. 615-623.
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