Application of a new preclinical drug screening system for cancer of the large bowel

Werner Scheithauer, Mary P. Moyer, Gary M. Clark, Daniel D. Von Hoff

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We report a prospective evaluation of three human, continuous colorectal cancer cell lines and a new semiautomated radiometric technique (Bactec system) as a primary screening procedure for cytotoxic compounds with activity against cancer of the large bowel. COLO 320DM, Ht-29, and the metastatic OM-1 colon cancer cell line that have previously been shown to yield clinically relevant information in terms of drug sensitivity patterns in humans were all tested against 11 new compounds currently being investigated in phase I or early phase II clinical trials. Our results suggest that trimetrexate, DUP-785, didemnin B, and flavone-8-acetic acid may be clinically effective for the treatment of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalCancer chemotherapy and pharmacology
Volume21
Issue number1
DOIs
StatePublished - Feb 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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