Apparent cross-reactivity of airborne molds and the dermatophytic fungi

Henry E. Jones, Michael G. Rinaldi, Hyman Chai, Guinter Kahn

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Forty-one asthmatic children, 10 to 16.5 years of age, were studied for evidence of infection with dermatophytic fungi. No evidence of past or current infection could be obtained, yet 16, or 39 per cent, showed an immediate allergic reaction to a galactomannan peptide (trichophytin) extracted from Trichophyton mentagrophytes. Thirteen of these 16 children (81 per cent) also had immediate allergic reactions to antigens extracted from nonpathogenic, airborne molds. The antibody, presumably IgE, responsible for type I allergic reactions to airborne molds, apparently crossreacts with antigens from the fungi pathogenic for human skin.

Original languageEnglish (US)
Pages (from-to)346-351
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume52
Issue number6
DOIs
StatePublished - Dec 1973
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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