Apolipoprotein B (apo B) signal peptide length polymorphisms are associated with apo B, low density lipoprotein cholesterol, and glucose levels in Mexican Americans

Candace M. Kammerer, John L. VandeBerg, Steven M. Haffner, James E. Hixson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We investigated the effects of apolipoprotein (apo) B signal peptide length polymorphisms on low density lipoprotein cholesterol (LDL-C), apo B, and post-challenge (2 h) glucose levels in 686 Mexican Americans from 34 families. The most common allele encoded an apo B signal peptide of 27 amino acids (ins; SP-27), the next most frequent allele encoded a 24 amino acid signal peptide (del; SP-24), and the rarest allele encoded a 29 amino acid signal peptide (ins*; SP-29) that has been found only in Mexican Americans. Homozygotes for the SP-24 allele had significantly higher mean levels of apo B, LDL-C, and 2-h glucose than SP-27 homozygotes, and SP-27/SP-24 heterozygotes had intermediate levels (P = 0.01 for apo B, P < 0.001 for LDL-C, and P = 0.04 for 2-h glucose). Heterozygotes for the SP-29 allele had higher apo B and LDL-C levels compared to homozygotes for the SP-27 or SP-24 alleles. Apo B signal peptide length polymorphism accounted for 4.2%, 3.5%, and 3.0% of the residual variation in LDL-C, apo B, and 2-h glucose levels, respectively, among the Mexican American families.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalAtherosclerosis
Volume120
Issue number1-2
DOIs
StatePublished - Feb 1996
Externally publishedYes

Keywords

  • Apolipoprotein B
  • Genetics
  • Glucose
  • Lipids
  • Mexican Americans

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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