APOE and mild cognitive impairment: The Framingham heart study

Angela L. Jefferson, Alexa S. Beiser, Sudha Seshadri, Philip A. Wolf, Rhoda Au

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: the risk apolipoprotein E-4 (APOE4) poses for mild cognitive impairment (MCI) may vary based on the neuropsychological definition of MCI.Setting: a community-based cohort study.Methods: using two psychometric neuropsychological impairment definitions, we examined APOE4 and prevalent MCI among older adults or pre-MCI among middle-aged adults. Neuropsychological, clinical and genetic data were collected on 2,239 Framingham Offspring Cohort participants free from clinical stroke or dementia (62 ± 9 years; 54% women). Prevalent amnestic MCI was defined from neuropsychological performances ≥1.5 SD below the mean based on (i) age and education or (ii) age and Wide Range Achievement Test-3 Reading (WRAT-3 Reading) performance adjustment.Results: in the entire sample, multivariable-adjusted logistic regressions found that APOE4 was associated with amnestic MCI when using the age and WRAT Reading definition (odds ratio [OR] = 1.7, P = 0.002) but not the age and education definition (OR = 1.0, P = 0.90). Results were modified by age, such that APOE4 was associated with amnestic MCI in participants ≥65 years using both the age and WRAT Reading definition (OR = 2.4, P < 0.001) and the age and education definition (OR = 1.7, P = 0.04).Conclusion: APOE4 risk for prevalent amnestic MCI varies depending on the definition of objective neuropsychological impairment for MCI. Our findings support existing literature emphasising the need to refine MCI neuropsychological profiling methods.

Original languageEnglish (US)
Article numberafu183
Pages (from-to)307-311
Number of pages5
JournalAge and Ageing
Volume44
Issue number2
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Keywords

  • APOE
  • Alzheimer's disease
  • Genetic risk
  • Mild cognitive impairment
  • Older people
  • Risk factors

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Jefferson, A. L., Beiser, A. S., Seshadri, S., Wolf, P. A., & Au, R. (2015). APOE and mild cognitive impairment: The Framingham heart study. Age and Ageing, 44(2), 307-311. [afu183]. https://doi.org/10.1093/ageing/afu183