APOE-ε3 and APOE -219G haplotypes increase the risk for schizophrenia in sibling pairs

Carlos Tovilla-Zarate; Beatriz Camarena Medellin; Ana Fresan; Rogelio Apiquian; Albana Dassori; Medina Rolando; Michael Escamilla; Humberto Nicolini

doi:10.1176/jnp.2009.21.4.440

APOE-ε3 and APOE -219G haplotypes increase the risk for schizophrenia in sibling pairs

Carlos Tovilla-Zarate, Beatriz Camarena Medellin, Ana Fresan, Rogelio Apiquian, Albana Dassori, Medina Rolando, Michael Escamilla, Humberto Nicolini

Psychiatry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-ε3 (χ²=6.24, p=0.01); this allele is mainly carried by female patients (χ²=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-ε3/APOE-219G are associated with schizophrenia (χ²=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.

Original language	English (US)
Pages (from-to)	440-444
Number of pages	5
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	21
Issue number	4
DOIs	https://doi.org/10.1176/jnp.2009.21.4.440
State	Published - 2009

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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APOE-ε3 and APOE -219G haplotypes increase the risk for schizophrenia in sibling pairs. / Tovilla-Zarate, Carlos; Camarena Medellin, Beatriz; Fresan, Ana; Apiquian, Rogelio; Dassori, Albana; Rolando, Medina; Escamilla, Michael; Nicolini, Humberto.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 21, No. 4, 2009, p. 440-444.

Research output: Contribution to journal › Article › peer-review

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abstract = "To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-ε3 (χ2=6.24, p=0.01); this allele is mainly carried by female patients (χ2=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-ε3/APOE-219G are associated with schizophrenia (χ2=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.",

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AU - Tovilla-Zarate, Carlos

AU - Camarena Medellin, Beatriz

AU - Fresan, Ana

AU - Apiquian, Rogelio

AU - Dassori, Albana

AU - Rolando, Medina

AU - Escamilla, Michael

AU - Nicolini, Humberto

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