TY - JOUR
T1 - APOE-ε3 and APOE -219G haplotypes increase the risk for schizophrenia in sibling pairs
AU - Tovilla-Zarate, Carlos
AU - Camarena Medellin, Beatriz
AU - Fresan, Ana
AU - Apiquian, Rogelio
AU - Dassori, Albana
AU - Rolando, Medina
AU - Escamilla, Michael
AU - Nicolini, Humberto
PY - 2009
Y1 - 2009
N2 - To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-ε3 (χ2=6.24, p=0.01); this allele is mainly carried by female patients (χ2=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-ε3/APOE-219G are associated with schizophrenia (χ2=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.
AB - To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-ε3 (χ2=6.24, p=0.01); this allele is mainly carried by female patients (χ2=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-ε3/APOE-219G are associated with schizophrenia (χ2=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.
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U2 - 10.1176/jnp.2009.21.4.440
DO - 10.1176/jnp.2009.21.4.440
M3 - Article
C2 - 19996253
AN - SCOPUS:85047684630
VL - 21
SP - 440
EP - 444
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
SN - 0895-0172
IS - 4
ER -