Abstract
Investigators in eight communities collected aortas, right coronary arteries, blood and liver samples, and associated information from 872 young males, aged 15-34 years, who died of external causes. Pathologists graded the arteries for atherosclerotic lesions, and a central laboratory measured lipoprotein cholesterol concentrations. Apolipoprotein (apo) B sequences were amplified in hepatic DNA samples to determine genotypes for length polymorphisms in the signal peptide of apo B. In addition to the insertion (ins) allele (27-amino acid signal peptide) and the deletion (del) allele (24 amino acids), we detected a rare allele (ins) in whites with an in-frame insertion of two Leu codons in a region that normally contains six Leu codons. The frequency for the apo B del allele was lower in blacks than in whites (p<0.0001). In blacks, homozygotes for the ins allele had the lowest levels of serum cholesterol and very low plus low density lipoprotein cholesterol (VLDL+LDL-C), homozygotes for the del allele had the highest levels, and heterozygotes had intermediate levels (p=0.0509 for cholesterol, p=0.0530 for VLDL+LDL-C), but no differences were found in whites. In blacks, homozygotes for the ins allele had the least involvement of the thoracic and the abdominal aorta with lesions, homozygotes for the del allele had the greatest involvement, and heterozygotes had intermediate involvement ( p=0.0328 for thoracic aorta, p=0.0104 for abdominal aorta), but no differences were found in whites. In blacks, apo B ins/del genotype accounted for 1.2% of the observed variation in lesions of the thoracic aorta and 1.7% of the variation in those of the abdominal aorta. The association of apo B ins/del genotypes with lesions in young blacks but not in young whites may contribute to explaining the excess of fatty streaks previously observed in young blacks.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1023-1029 |
| Number of pages | 7 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 12 |
| Issue number | 9 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Abdominal aorta
- Apolipoprotein B
- Apolipoprotein E
- Atherosclerosis
- Lipoprotein cholesterol
- Polymorphisms
- Right coronary artery
- Serum cholesterol
- Thoracic aorta
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Apo B insertion/deletion polymorphisms are associated with atherosclerosis in young black but not young white males. / Hixson, James E.; Alex McMahan, C.; McGill, Henry C.; Strong, Jack P.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 12, No. 9, 1992, p. 1023-1029.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apo B insertion/deletion polymorphisms are associated with atherosclerosis in young black but not young white males
AU - Hixson, James E.
AU - Alex McMahan, C.
AU - McGill, Henry C.
AU - Strong, Jack P.
PY - 1992
Y1 - 1992
N2 - Investigators in eight communities collected aortas, right coronary arteries, blood and liver samples, and associated information from 872 young males, aged 15-34 years, who died of external causes. Pathologists graded the arteries for atherosclerotic lesions, and a central laboratory measured lipoprotein cholesterol concentrations. Apolipoprotein (apo) B sequences were amplified in hepatic DNA samples to determine genotypes for length polymorphisms in the signal peptide of apo B. In addition to the insertion (ins) allele (27-amino acid signal peptide) and the deletion (del) allele (24 amino acids), we detected a rare allele (ins) in whites with an in-frame insertion of two Leu codons in a region that normally contains six Leu codons. The frequency for the apo B del allele was lower in blacks than in whites (p<0.0001). In blacks, homozygotes for the ins allele had the lowest levels of serum cholesterol and very low plus low density lipoprotein cholesterol (VLDL+LDL-C), homozygotes for the del allele had the highest levels, and heterozygotes had intermediate levels (p=0.0509 for cholesterol, p=0.0530 for VLDL+LDL-C), but no differences were found in whites. In blacks, homozygotes for the ins allele had the least involvement of the thoracic and the abdominal aorta with lesions, homozygotes for the del allele had the greatest involvement, and heterozygotes had intermediate involvement ( p=0.0328 for thoracic aorta, p=0.0104 for abdominal aorta), but no differences were found in whites. In blacks, apo B ins/del genotype accounted for 1.2% of the observed variation in lesions of the thoracic aorta and 1.7% of the variation in those of the abdominal aorta. The association of apo B ins/del genotypes with lesions in young blacks but not in young whites may contribute to explaining the excess of fatty streaks previously observed in young blacks.
AB - Investigators in eight communities collected aortas, right coronary arteries, blood and liver samples, and associated information from 872 young males, aged 15-34 years, who died of external causes. Pathologists graded the arteries for atherosclerotic lesions, and a central laboratory measured lipoprotein cholesterol concentrations. Apolipoprotein (apo) B sequences were amplified in hepatic DNA samples to determine genotypes for length polymorphisms in the signal peptide of apo B. In addition to the insertion (ins) allele (27-amino acid signal peptide) and the deletion (del) allele (24 amino acids), we detected a rare allele (ins) in whites with an in-frame insertion of two Leu codons in a region that normally contains six Leu codons. The frequency for the apo B del allele was lower in blacks than in whites (p<0.0001). In blacks, homozygotes for the ins allele had the lowest levels of serum cholesterol and very low plus low density lipoprotein cholesterol (VLDL+LDL-C), homozygotes for the del allele had the highest levels, and heterozygotes had intermediate levels (p=0.0509 for cholesterol, p=0.0530 for VLDL+LDL-C), but no differences were found in whites. In blacks, homozygotes for the ins allele had the least involvement of the thoracic and the abdominal aorta with lesions, homozygotes for the del allele had the greatest involvement, and heterozygotes had intermediate involvement ( p=0.0328 for thoracic aorta, p=0.0104 for abdominal aorta), but no differences were found in whites. In blacks, apo B ins/del genotype accounted for 1.2% of the observed variation in lesions of the thoracic aorta and 1.7% of the variation in those of the abdominal aorta. The association of apo B ins/del genotypes with lesions in young blacks but not in young whites may contribute to explaining the excess of fatty streaks previously observed in young blacks.
KW - Abdominal aorta
KW - Apolipoprotein B
KW - Apolipoprotein E
KW - Atherosclerosis
KW - Lipoprotein cholesterol
KW - Polymorphisms
KW - Right coronary artery
KW - Serum cholesterol
KW - Thoracic aorta
UR - http://www.scopus.com/inward/record.url?scp=0026688234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026688234&partnerID=8YFLogxK
M3 - Article
C2 - 1525116
AN - SCOPUS:0026688234
VL - 12
SP - 1023
EP - 1029
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 9
ER -