Aortic stiffness: Pathophysiology, clinical implications, and approach to treatment

Salil Sethi, Oscar Rivera, Rene Oliveros, Robert Chilton

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Aortic stiffness is a hallmark of aging, and classic cardiovascular risk factors play a role in accelerating this process. Current changes in medicine, which focus on preventive care, have led to a growing interest in noninvasive evaluation of aortic stiffness. Aortic stiffness has emerged as a good tool for further risk stratification because it has been linked to increased risk of atherosclerotic heart disease, myocardial infarction, heart failure, and stroke. This has led to the invention and validation of multiple methods to measure aortic stiffness. Pulse wave velocity is emerging as the gold standard for evaluation of aortic stiffness. This review focuses on the pathophysiology involved in aortic stiffness, methods available for evaluation of aortic stiffness, the importance of central pressure as a predictor of future cardiovascular events, and therapies that affect aortic stiffness.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalIntegrated Blood Pressure Control
Issue number1
StatePublished - May 23 2014


  • Aortic stiffness
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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