Aortic stiffness: Pathophysiology, clinical implications, and approach to treatment

Salil Sethi, Oscar Rivera, Rene A Oliveros, Robert J Chilton

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Aortic stiffness is a hallmark of aging, and classic cardiovascular risk factors play a role in accelerating this process. Current changes in medicine, which focus on preventive care, have led to a growing interest in noninvasive evaluation of aortic stiffness. Aortic stiffness has emerged as a good tool for further risk stratification because it has been linked to increased risk of atherosclerotic heart disease, myocardial infarction, heart failure, and stroke. This has led to the invention and validation of multiple methods to measure aortic stiffness. Pulse wave velocity is emerging as the gold standard for evaluation of aortic stiffness. This review focuses on the pathophysiology involved in aortic stiffness, methods available for evaluation of aortic stiffness, the importance of central pressure as a predictor of future cardiovascular events, and therapies that affect aortic stiffness.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalIntegrated Blood Pressure Control
Volume7
Issue number1
DOIs
StatePublished - May 23 2014

Fingerprint

Vascular Stiffness
Pulse Wave Analysis
Preventive Medicine
Heart Diseases
Heart Failure
Stroke
Myocardial Infarction
Medicine
Pressure

Keywords

  • Aortic stiffness
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Aortic stiffness : Pathophysiology, clinical implications, and approach to treatment. / Sethi, Salil; Rivera, Oscar; Oliveros, Rene A; Chilton, Robert J.

In: Integrated Blood Pressure Control, Vol. 7, No. 1, 23.05.2014, p. 29-34.

Research output: Contribution to journalArticle

Sethi, Salil ; Rivera, Oscar ; Oliveros, Rene A ; Chilton, Robert J. / Aortic stiffness : Pathophysiology, clinical implications, and approach to treatment. In: Integrated Blood Pressure Control. 2014 ; Vol. 7, No. 1. pp. 29-34.
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