Aortic baroreceptor deafferentation in the baboon

V. S. Bishop, J. R. Haywood, R. E. Shade, M. Siegel, C. Hamm

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    Previous animal studies have indicated that removal of the aortic baroreceptors causes a moderate increase in arterial pressure that is not fully buffered by receptors in the carotid sinus. However, the role of these separate baroreceptors in the conscious nonhuman primate has not been examined. To address this question, adult male baboons were chronically maintained on a tether system that permitted them to move freely about their cage. With this system, arterial pressure and heart rate could be monitored continuously over 24-h periods with periodic drug administration to test cardiovascular function. Control values of arterial pressure and heart rate were 85.6 ± 4.0 mmHg and 77.5 ± 2.9 beats/min, respectively. Following removal of the aortic baroreceptors, arterial pressure rose to 104.6 ± 5.5 mmHg and heart rate increased to 117.9 ± 3.1 beats/min. The variability of these parameters did not change following denervation. There was, however, a suppression of the arterial pressure-heart period relationship and an augmentation in the depressor response to ganglionic blockade with hexamethonium. These data indicate that removal of the aortic baroreceptors causes a reduction in the sensitivity of the heart rate baroreflex and subsequent increase in arterial pressure that is a result of an increased sympathetic nervous system function.

    Original languageEnglish (US)
    Pages (from-to)798-801
    Number of pages4
    JournalJournal of applied physiology
    Volume60
    Issue number3
    StatePublished - Nov 19 1986

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

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