Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise

Peter J. Houghton; Janet A. Houghton

doi:10.1007/BF00194530

Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise

Peter J. Houghton, Janet A. Houghton

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

Original language	English (US)
Pages (from-to)	271-280
Number of pages	10
Journal	Investigational New Drugs
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/BF00194530
State	Published - 1996
Externally published	Yes

Keywords

Diarylsulfonylureas
Pharmacology
Xenografts

ASJC Scopus subject areas

Pharmacology (medical)
Oncology
Pharmacology

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10.1007/BF00194530

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abstract = "Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.",

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AU - Houghton, Peter J.

AU - Houghton, Janet A.

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N2 - Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

AB - Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2,3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

KW - Diarylsulfonylureas

KW - Pharmacology

KW - Xenografts

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ER -

Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise

Abstract

Keywords

ASJC Scopus subject areas

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