Antithyroid effect of chlorpropamide?

J. Feely, S. McLaren, Alexander M Shepherd, D. Maclean, I. H. Stevenson, C. G. Swift, T. E. Isles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r=0.33, p<0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. Serum thyroxine was negatively correlated with the duration of diabetes in both groups. These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalHuman Toxicology
Volume2
Issue number1
StatePublished - 1983
Externally publishedYes

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Chlorpropamide
Antithyroid Agents
Thyroxine
Serum
Plasmas
Thyrotropin
Nutrition
Medical problems
Thyroid Gland
Research Design
Diet
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Feely, J., McLaren, S., Shepherd, A. M., Maclean, D., Stevenson, I. H., Swift, C. G., & Isles, T. E. (1983). Antithyroid effect of chlorpropamide? Human Toxicology, 2(1), 149-153.

Antithyroid effect of chlorpropamide? / Feely, J.; McLaren, S.; Shepherd, Alexander M; Maclean, D.; Stevenson, I. H.; Swift, C. G.; Isles, T. E.

In: Human Toxicology, Vol. 2, No. 1, 1983, p. 149-153.

Research output: Contribution to journalArticle

Feely, J, McLaren, S, Shepherd, AM, Maclean, D, Stevenson, IH, Swift, CG & Isles, TE 1983, 'Antithyroid effect of chlorpropamide?', Human Toxicology, vol. 2, no. 1, pp. 149-153.
Feely J, McLaren S, Shepherd AM, Maclean D, Stevenson IH, Swift CG et al. Antithyroid effect of chlorpropamide? Human Toxicology. 1983;2(1):149-153.
Feely, J. ; McLaren, S. ; Shepherd, Alexander M ; Maclean, D. ; Stevenson, I. H. ; Swift, C. G. ; Isles, T. E. / Antithyroid effect of chlorpropamide?. In: Human Toxicology. 1983 ; Vol. 2, No. 1. pp. 149-153.
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