Antithyroid effect of chlorpropamide?

J. Feely, S. McLaren, A. M.M. Shepherd, D. Maclean, I. H. Stevenson, C. G. Swift, T. E. Isles

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r=0.33, p<0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. Serum thyroxine was negatively correlated with the duration of diabetes in both groups. These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalUnknown Journal
Issue number1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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