Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: Identification and genetics

Kevin Bell; Helen Arthur; Roland A H van Oorschot; John L. VandeBerg

doi:10.1007/PL00020520

Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: Identification and genetics

Kevin Bell, Helen Arthur, Roland A H van Oorschot, John L. VandeBerg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2–4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3^A, AT3^B, and AT3^C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.

Original language	English (US)
Pages (from-to)	591-601
Number of pages	11
Journal	Biochemical Genetics
Volume	30
Issue number	11
DOIs	https://doi.org/10.1007/PL00020520
State	Published - 1992
Externally published	Yes

Keywords

antithrombin III
genetics
Monodelphis domestica
polymorphism

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Genetics
Molecular Biology

Access to Document

10.1007/PL00020520

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title = "Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: Identification and genetics",

abstract = "Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2–4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.",

keywords = "antithrombin III, genetics, Monodelphis domestica, polymorphism",

author = "Kevin Bell and Helen Arthur and {van Oorschot}, {Roland A H} and VandeBerg, {John L.}",

year = "1992",

doi = "10.1007/PL00020520",

language = "English (US)",

volume = "30",

pages = "591--601",

journal = "Biochemical Genetics",

issn = "0006-2928",

publisher = "Springer New York",

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T1 - Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica

T2 - Identification and genetics

AU - Bell, Kevin

AU - Arthur, Helen

AU - van Oorschot, Roland A H

AU - VandeBerg, John L.

PY - 1992

Y1 - 1992

N2 - Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2–4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.

AB - Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2–4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.

KW - antithrombin III

KW - genetics

KW - Monodelphis domestica

KW - polymorphism

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