Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: Identification and genetics

Kevin Bell, Helen Arthur, Roland A H van Oorschot, John L. VandeBerg

Research output: Contribution to journalArticlepeer-review

Abstract

Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2-4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.

Original languageEnglish (US)
Pages (from-to)591-601
Number of pages11
JournalBiochemical Genetics
Volume30
Issue number11-12
DOIs
StatePublished - Dec 1992
Externally publishedYes

Keywords

  • antithrombin III
  • genetics
  • Monodelphis domestica
  • polymorphism

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

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