Antisocial personality disorder and alcohol-induced aggression

F. Gerard Moeller, Donald M. Dougherty, Scott D. Lane, Joel L. Steinberg, Don R. Cherek

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


This study compared the effects of alcohol on aggressive responding between subjects with antisocial personality disorder (ASPD) and subjects without ASPD. Eighteen alcohol drinking subjects (10 subjects without ASPD and 8 subjects with ASPD) underwent testing on a laboratory measure of aggression, the Point Subtraction Aggression Paradigm, after consumption of placebo and three doses of alcohol (0.25 g/kg, 0.5 g/kg, and 1.0 g/kg). There was a significant difference in the effect of alcohol on aggressive responding on the Point Subtraction Aggression Paradigm between subjects with ASPD and subjects without ASPD. Subjects with ASPD had a greater increase in aggressive responding after alcohol, compared with non-ASPD subjects. There was no difference between the two groups in the effect of alcohol on monetary-reinforced responding.

Original languageEnglish (US)
Pages (from-to)1898-1902
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Issue number9
StatePublished - Dec 1998
Externally publishedYes


  • Aggression
  • Alcohol
  • Antisocial Personality Disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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