Antisense Oligonucleotides from the Stage-specific Myeloid Zinc Finger Gene MZF-1 Inhibit Granulopoiesis In Vitro

Linda Bavisotto, Kenneth Kaushansky, Nancy Lin, Robert Hromas

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary radiolabeled MZF-1 tLNA hybridized to human bone marrow smears in situ, it was discovered that the expression of MZF-1 is essentially limited to the myelocyte and metamyelocyte stages of granulopoiesis. Antisense but not sense oligonucleotides from MZF-1 significantly inhibited granulocyte colony-stimulating factor-driven granulocyte colony formation in vitro.

Original languageEnglish (US)
Pages (from-to)1097-1101
Number of pages5
JournalJournal of Experimental Medicine
Volume174
Issue number5
DOIs
StatePublished - Nov 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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