Abstract
Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary radiolabeled MZF-1 tLNA hybridized to human bone marrow smears in situ, it was discovered that the expression of MZF-1 is essentially limited to the myelocyte and metamyelocyte stages of granulopoiesis. Antisense but not sense oligonucleotides from MZF-1 significantly inhibited granulocyte colony-stimulating factor-driven granulocyte colony formation in vitro.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1097-1101 |
| Number of pages | 5 |
| Journal | Journal of Experimental Medicine |
| Volume | 174 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 1991 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Bavisotto, L., Kaushansky, K., Lin, N., & Hromas, R. (1991). Antisense Oligonucleotides from the Stage-specific Myeloid Zinc Finger Gene MZF-1 Inhibit Granulopoiesis In Vitro. Journal of Experimental Medicine, 174(5), 1097-1101. https://doi.org/10.1084/jem.174.5.1097