Abstract
Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary radiolabeled MZF-1 RNA hybridized to human bone marrow smears in situ, it was discovered that the expression of MZF-1 is essentially limited to the myelocyte and metamyelocyte stages of granulopoiesis. Antisense but not sense oligonucleotides from MZF-1 significantly inhibited granulocyte colony-stimulating factor-driven granulocyte colony formation in vitro.
Original language | English (US) |
---|---|
Pages (from-to) | 1097-1101 |
Number of pages | 5 |
Journal | Journal of Experimental Medicine |
Volume | 174 |
Issue number | 5 |
State | Published - Nov 1 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology