Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: Data from the COGS study

Allen D. Radant, Dorcas J. Dobie, Monica E. Calkins, Ann Olincy, David L. Braff, Kristin S. Cadenhead, Robert Freedman, Michael F. Green, Tiffany A. Greenwood, Raquel E. Gur, Ruben C. Gur, Gregory A. Light, Sean P. Meichle, Steve P. Millard, Jim Mintz, Keith H. Nuechterlein, Nicholas J. Schork, Larry J. Seidman, Larry J. Siever, Jeremy M. SilvermanWilliam S. Stone, Neal R. Swerdlow, Ming T. Tsuang, Bruce I. Turetsky, Debby W. Tsuang

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The antisaccade task is a widely used technique to measure failure of inhibition, an important cause of cognitive and clinical abnormalities found in schizophrenia. Although antisaccade performance, which reflects the ability to inhibit prepotent responses, is a putative schizophrenia endophenotype, researchers have not consistently reported the expected differences between first-degree relatives and comparison groups. Schizophrenia participants (n=219) from the large Consortium on the Genetics of Schizophrenia (COGS) sample (n=1078) demonstrated significant deficits on an overlap version of the antisaccade task compared to their first-degree relatives (n=443) and community comparison subjects (CCS; n=416). Although mean antisaccade performance of first-degree relatives was intermediate between schizophrenia participants and CCS, a linear mixed-effects model adjusting for group, site, age, and gender found no significant performance differences between the first-degree relatives and CCS. However, admixture analyses showed that two components best explained the distributions in all three groups, suggesting two distinct doses of an etiological factor. Given the significant heritability of antisaccade performance, the effects of a genetic polymorphism is one possible explanation of our results. Journal Compilation

Original languageEnglish (US)
Pages (from-to)846-856
Number of pages11
JournalPsychophysiology
Volume47
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • Antisaccade
  • Endophenotype
  • Family
  • Oculomotor
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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