Antipsychotic treatment in breast cancer patients

Tahir Rahman, Charles V. Clevenger, Virginia Kaklamani, John Lauriello, Austin Campbell, Kari Malwitz, Robert S. Kirkland

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Special consideration is required when prescribing antipsychotic drugs for patients with an existing diagnosis of breast cancer. The package inserts of all approved antipsychotics contain precautions regarding their administration in this patient group. These drugs are well known to elevate serum prolactin levels to varying degrees. Overexpression of the prolactin receptor is seen in more than 95% of human breast cancers. Many genes that are activated by the prolactin receptor are associated with tumorigenesis and cancer cell proliferation. The authors discuss the pathophysiology, clinical implications, and pertinent preclinical data and make specific recommendations regarding the use of antipsychotics in patients with breast cancer.

Original languageEnglish (US)
Pages (from-to)616-621
Number of pages6
JournalAmerican Journal of Psychiatry
Volume171
Issue number6
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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