TY - JOUR
T1 - Antipsychotic treatment experiences of people with bipolar i disorder
T2 - Patient perspectives from an online survey
AU - Bessonova, Leona
AU - Velligan, Dawn I.
AU - Weiden, Peter J.
AU - O'Sullivan, Amy K.
AU - Yarlas, Aaron
AU - Bayliss, Martha
AU - Baranwal, Nishtha
AU - Rychlec, Kaitlin
AU - Carpenter-Conlin, Julia
AU - Doane, Michael J.
AU - Sajatovic, Martha
N1 - Funding Information:
This research was funded by Alkermes, Inc. The study sponsor was involved in research design, data interpretation, and drafting of the article.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/7/6
Y1 - 2020/7/6
N2 - Background: Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use. Methods: Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and preferences for a hypothetical AP were also examined. Analyses were descriptive. Results: The survey sample had a mean age of 43.2 (SD = 12.4) years, was 60% female, and 31% nonwhite. Almost all participants (98%) had experienced AP side effects. Common self-reported side effects were feeling drowsy or tired (83%), lack of emotion (79%), anxiety (79%), dry mouth (76%), and weight gain (76%). Weight gain was cited as the most bothersome side effect, rated by most participants (68%) as "very"or "extremely bothersome."Nearly half of participants (49%) reported that AP side effects negatively impacted their job performance; almost all (92%) reported that side effects-most commonly anxiety and lack of emotion-negatively impacted social relationships (e.g., family or romantic partners). The most commonly-reported reason for stopping AP use was dislike of side effects (48%). Side effects most likely to lead to stopping or taking less of AP treatment included "feeling like a 'zombie'"(29%), feeling drowsy or tired (25%), and weight gain (24%). When considering a hypothetical new AP, the most common side effects participants wanted to avoid included AP-induced anxiety (50%), weight gain (48%), and "feeling like a 'zombie'"(47%). Conclusions: Side effects of APs were both common and bothersome, and impacted social functioning, adherence, and work. Findings highlight the prevailing unmet need for new APs with more favorable benefit-risk profiles.
AB - Background: Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use. Methods: Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and preferences for a hypothetical AP were also examined. Analyses were descriptive. Results: The survey sample had a mean age of 43.2 (SD = 12.4) years, was 60% female, and 31% nonwhite. Almost all participants (98%) had experienced AP side effects. Common self-reported side effects were feeling drowsy or tired (83%), lack of emotion (79%), anxiety (79%), dry mouth (76%), and weight gain (76%). Weight gain was cited as the most bothersome side effect, rated by most participants (68%) as "very"or "extremely bothersome."Nearly half of participants (49%) reported that AP side effects negatively impacted their job performance; almost all (92%) reported that side effects-most commonly anxiety and lack of emotion-negatively impacted social relationships (e.g., family or romantic partners). The most commonly-reported reason for stopping AP use was dislike of side effects (48%). Side effects most likely to lead to stopping or taking less of AP treatment included "feeling like a 'zombie'"(29%), feeling drowsy or tired (25%), and weight gain (24%). When considering a hypothetical new AP, the most common side effects participants wanted to avoid included AP-induced anxiety (50%), weight gain (48%), and "feeling like a 'zombie'"(47%). Conclusions: Side effects of APs were both common and bothersome, and impacted social functioning, adherence, and work. Findings highlight the prevailing unmet need for new APs with more favorable benefit-risk profiles.
KW - Adherence
KW - Antipsychotic
KW - Bipolar I disorder
KW - Bipolar disorder
KW - Preference
KW - Side effects
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U2 - 10.1186/s12888-020-02767-x
DO - 10.1186/s12888-020-02767-x
M3 - Review article
C2 - 32631362
AN - SCOPUS:85087702249
SN - 1471-244X
VL - 20
JO - BMC Psychiatry
JF - BMC Psychiatry
IS - 1
M1 - 354
ER -