Antipsychotic medication and social cue recognition in chronic schizophrenia

David Leland Roberts, David Lewis Penn, Patrick Corrigan, Ilya Lipkovich, Bruce Kinon, Ryan Andrew Black

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalPsychiatry Research
Issue number1
StatePublished - Jun 30 2010
Externally publishedYes


  • Signal detection
  • Social cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Antipsychotic medication and social cue recognition in chronic schizophrenia'. Together they form a unique fingerprint.

Cite this