Antipsychotic medication and social cue recognition in chronic schizophrenia

David Roberts, David Lewis Penn, Patrick Corrigan, Ilya Lipkovich, Bruce Kinon, Ryan Andrew Black

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalPsychiatry Research
Volume178
Issue number1
DOIs
StatePublished - Jun 30 2010
Externally publishedYes

Fingerprint

Cognition
Antipsychotic Agents
Cues
Schizophrenia
olanzapine
Research
Recognition (Psychology)
Quality of Life
Clinical Trials

Keywords

  • Signal detection
  • Social cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Antipsychotic medication and social cue recognition in chronic schizophrenia. / Roberts, David; Penn, David Lewis; Corrigan, Patrick; Lipkovich, Ilya; Kinon, Bruce; Black, Ryan Andrew.

In: Psychiatry Research, Vol. 178, No. 1, 30.06.2010, p. 46-50.

Research output: Contribution to journalArticle

Roberts, David ; Penn, David Lewis ; Corrigan, Patrick ; Lipkovich, Ilya ; Kinon, Bruce ; Black, Ryan Andrew. / Antipsychotic medication and social cue recognition in chronic schizophrenia. In: Psychiatry Research. 2010 ; Vol. 178, No. 1. pp. 46-50.
@article{56f68ad28bce436cbd9f178e0e3b5e56,
title = "Antipsychotic medication and social cue recognition in chronic schizophrenia",
abstract = "Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.",
keywords = "Signal detection, Social cognition",
author = "David Roberts and Penn, {David Lewis} and Patrick Corrigan and Ilya Lipkovich and Bruce Kinon and Black, {Ryan Andrew}",
year = "2010",
month = "6",
day = "30",
doi = "10.1016/j.psychres.2010.04.006",
language = "English (US)",
volume = "178",
pages = "46--50",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Antipsychotic medication and social cue recognition in chronic schizophrenia

AU - Roberts, David

AU - Penn, David Lewis

AU - Corrigan, Patrick

AU - Lipkovich, Ilya

AU - Kinon, Bruce

AU - Black, Ryan Andrew

PY - 2010/6/30

Y1 - 2010/6/30

N2 - Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.

AB - Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication use and social cognition. This study evaluated whether individuals treated with olanzapine (n=117) or quetiapine (n=106) achieved improvements in social cognition. Participants were drawn from a larger 6-month, multi-site, randomized, double-blind clinical trial. Social cognition was assessed using signal detection analysis of performance on the Social Cue Recognition Test. Social functioning was measured with an interpersonal functioning index and a broader quality of life measure. Results revealed that participants in both medication groups improved significantly but modestly on three out of four social cognition subscales. The small observed effect in this trial is generally consistent with previous studies, and supports the need for ongoing research into the biological mechanisms of social cognitive dysfunction in schizophrenia.

KW - Signal detection

KW - Social cognition

UR - http://www.scopus.com/inward/record.url?scp=77956913292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956913292&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2010.04.006

DO - 10.1016/j.psychres.2010.04.006

M3 - Article

C2 - 20452678

AN - SCOPUS:77956913292

VL - 178

SP - 46

EP - 50

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -