Antiproliferative effects of 12-oxoheteronemin vs heteronemin

Siriporn Kittiwisut, Cristina C. Rohena, Supreeya Yuenyongsawad, Susan L. Mooberry, Anuchit Plubrukarn

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 μM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.

Original languageEnglish (US)
Pages (from-to)359-360
Number of pages2
JournalNatural Product Communications
Volume9
Issue number3
StatePublished - 2014

Keywords

  • 12-Oxoheteronemin
  • Antiproliferation
  • Apoptosis
  • Heteronemin

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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    Kittiwisut, S., Rohena, C. C., Yuenyongsawad, S., Mooberry, S. L., & Plubrukarn, A. (2014). Antiproliferative effects of 12-oxoheteronemin vs heteronemin. Natural Product Communications, 9(3), 359-360.