Antiproliferative effects of 12-oxoheteronemin vs heteronemin

Siriporn Kittiwisut; Cristina C. Rohena; Supreeya Yuenyongsawad; Susan L. Mooberry; Anuchit Plubrukarn

Antiproliferative effects of 12-oxoheteronemin vs heteronemin

Siriporn Kittiwisut, Cristina C. Rohena, Supreeya Yuenyongsawad, Susan L. Mooberry, Anuchit Plubrukarn

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC₅₀ values ranging from 0.66 to 1.35 μM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G₁ populations of cells and caspase-dependent PARP cleavage.

Original language	English (US)
Pages (from-to)	359-360
Number of pages	2
Journal	Natural Product Communications
Volume	9
Issue number	3
State	Published - 2014

Keywords

12-Oxoheteronemin
Antiproliferation
Apoptosis
Heteronemin

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

Cite this

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title = "Antiproliferative effects of 12-oxoheteronemin vs heteronemin",

abstract = "The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 μM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.",

keywords = "12-Oxoheteronemin, Antiproliferation, Apoptosis, Heteronemin",

author = "Siriporn Kittiwisut and Rohena, {Cristina C.} and Supreeya Yuenyongsawad and Mooberry, {Susan L.} and Anuchit Plubrukarn",

year = "2014",

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volume = "9",

pages = "359--360",

journal = "Natural Product Communications",

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T1 - Antiproliferative effects of 12-oxoheteronemin vs heteronemin

AU - Kittiwisut, Siriporn

AU - Rohena, Cristina C.

AU - Yuenyongsawad, Supreeya

AU - Mooberry, Susan L.

AU - Plubrukarn, Anuchit

PY - 2014

Y1 - 2014

N2 - The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 μM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.

AB - The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 μM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.

KW - 12-Oxoheteronemin

KW - Antiproliferation

KW - Apoptosis

KW - Heteronemin

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M3 - Article

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AN - SCOPUS:84895475130

SN - 1934-578X

VL - 9

SP - 359

EP - 360

JO - Natural Product Communications

JF - Natural Product Communications

IS - 3

ER -

Antiproliferative effects of 12-oxoheteronemin vs heteronemin

Abstract

Keywords

ASJC Scopus subject areas

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