Antiphospholipid antibodies in stillbirth

Robert M. Silver, Corette B. Parker, Uma M. Reddy, Robert Goldenberg, Donald Coustan, Donald J. Dudley, George R. Saade, Barbara Stoll, Matthew A. Koch, Deborah L Conway, Radek Bukowski, Carol J. Rowland Hogue, Halit Pinar, Janet Moore, Marian Willinger, D. Ware Branch

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE:: To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS:: Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2- glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULTS:: Elevated levels of IgG anticardiolipin and IgG anti-β2-glycoprotein-I antibodies were associated with an approximate threefold increased odds of stillbirth (crude odds ratio [OR] 3.43, 95% confidence interval [CI] 1.79-6.60, 3.8% compared with 1.1% and OR 3.17, 95% CI 1.30-7.72, (1.9% compared with 0.6%, respectively) when all deliveries with stillbirth were compared with all deliveries with live birth. When the subset of stillbirths not associated with fetal anomalies or obstetric complications was compared with term live births, elevated IgG anticardiolipin antibodies were associated with stillbirth (5.0% compared with 1.0%; OR 5.30, 95% CI, 2.39-11.76; IgG anti-β2-glycoprotein-I antibodies (1.9% compared with 0.6%) had an OR of 3.00 (95% CI 1.01-8.90) and IgM anticardiolipin antibodies (6.0% compared with 3.0%) had an OR of 2.03 (95% CI 1.09-3.76). Elevated levels of anticardiolipin and anti-β2- glycoprotein-I antibodies were associated with a threefold to fivefold increased odds of stillbirth. CONCLUSIONS:: Our data support consideration of testing for antiphospholipid antibodies in cases of otherwise unexplained stillbirth.

Original languageEnglish (US)
Pages (from-to)641-657
Number of pages17
JournalObstetrics and Gynecology
Volume122
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

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Antiphospholipid Antibodies
Stillbirth
Live Birth
Odds Ratio
Confidence Intervals
Glycoproteins
Anticardiolipin Antibodies
Antibodies
Immunoglobulin G
Term Birth
Obstetrics
Immunoglobulin M
Case-Control Studies
Mothers

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Silver, R. M., Parker, C. B., Reddy, U. M., Goldenberg, R., Coustan, D., Dudley, D. J., ... Branch, D. W. (2013). Antiphospholipid antibodies in stillbirth. Obstetrics and Gynecology, 122(3), 641-657. https://doi.org/10.1097/AOG.0b013e3182a1060e

Antiphospholipid antibodies in stillbirth. / Silver, Robert M.; Parker, Corette B.; Reddy, Uma M.; Goldenberg, Robert; Coustan, Donald; Dudley, Donald J.; Saade, George R.; Stoll, Barbara; Koch, Matthew A.; Conway, Deborah L; Bukowski, Radek; Rowland Hogue, Carol J.; Pinar, Halit; Moore, Janet; Willinger, Marian; Branch, D. Ware.

In: Obstetrics and Gynecology, Vol. 122, No. 3, 09.2013, p. 641-657.

Research output: Contribution to journalArticle

Silver, RM, Parker, CB, Reddy, UM, Goldenberg, R, Coustan, D, Dudley, DJ, Saade, GR, Stoll, B, Koch, MA, Conway, DL, Bukowski, R, Rowland Hogue, CJ, Pinar, H, Moore, J, Willinger, M & Branch, DW 2013, 'Antiphospholipid antibodies in stillbirth', Obstetrics and Gynecology, vol. 122, no. 3, pp. 641-657. https://doi.org/10.1097/AOG.0b013e3182a1060e
Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ et al. Antiphospholipid antibodies in stillbirth. Obstetrics and Gynecology. 2013 Sep;122(3):641-657. https://doi.org/10.1097/AOG.0b013e3182a1060e
Silver, Robert M. ; Parker, Corette B. ; Reddy, Uma M. ; Goldenberg, Robert ; Coustan, Donald ; Dudley, Donald J. ; Saade, George R. ; Stoll, Barbara ; Koch, Matthew A. ; Conway, Deborah L ; Bukowski, Radek ; Rowland Hogue, Carol J. ; Pinar, Halit ; Moore, Janet ; Willinger, Marian ; Branch, D. Ware. / Antiphospholipid antibodies in stillbirth. In: Obstetrics and Gynecology. 2013 ; Vol. 122, No. 3. pp. 641-657.
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abstract = "OBJECTIVE:: To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS:: Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2- glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULTS:: Elevated levels of IgG anticardiolipin and IgG anti-β2-glycoprotein-I antibodies were associated with an approximate threefold increased odds of stillbirth (crude odds ratio [OR] 3.43, 95{\%} confidence interval [CI] 1.79-6.60, 3.8{\%} compared with 1.1{\%} and OR 3.17, 95{\%} CI 1.30-7.72, (1.9{\%} compared with 0.6{\%}, respectively) when all deliveries with stillbirth were compared with all deliveries with live birth. When the subset of stillbirths not associated with fetal anomalies or obstetric complications was compared with term live births, elevated IgG anticardiolipin antibodies were associated with stillbirth (5.0{\%} compared with 1.0{\%}; OR 5.30, 95{\%} CI, 2.39-11.76; IgG anti-β2-glycoprotein-I antibodies (1.9{\%} compared with 0.6{\%}) had an OR of 3.00 (95{\%} CI 1.01-8.90) and IgM anticardiolipin antibodies (6.0{\%} compared with 3.0{\%}) had an OR of 2.03 (95{\%} CI 1.09-3.76). Elevated levels of anticardiolipin and anti-β2- glycoprotein-I antibodies were associated with a threefold to fivefold increased odds of stillbirth. CONCLUSIONS:: Our data support consideration of testing for antiphospholipid antibodies in cases of otherwise unexplained stillbirth.",
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AU - Silver, Robert M.

AU - Parker, Corette B.

AU - Reddy, Uma M.

AU - Goldenberg, Robert

AU - Coustan, Donald

AU - Dudley, Donald J.

AU - Saade, George R.

AU - Stoll, Barbara

AU - Koch, Matthew A.

AU - Conway, Deborah L

AU - Bukowski, Radek

AU - Rowland Hogue, Carol J.

AU - Pinar, Halit

AU - Moore, Janet

AU - Willinger, Marian

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N2 - OBJECTIVE:: To compare antiphospholipid antibodies in deliveries with and without stillbirth using a multicenter, population-based case-control study of stillbirths and live births. METHODS:: Maternal sera were assayed for immunoglobulin (Ig)G and IgM anticardiolipin and anti-β2- glycoprotein-I antibodies. Assays were performed in 582 stillbirth deliveries and 1,547 live birth deliveries. RESULTS:: Elevated levels of IgG anticardiolipin and IgG anti-β2-glycoprotein-I antibodies were associated with an approximate threefold increased odds of stillbirth (crude odds ratio [OR] 3.43, 95% confidence interval [CI] 1.79-6.60, 3.8% compared with 1.1% and OR 3.17, 95% CI 1.30-7.72, (1.9% compared with 0.6%, respectively) when all deliveries with stillbirth were compared with all deliveries with live birth. When the subset of stillbirths not associated with fetal anomalies or obstetric complications was compared with term live births, elevated IgG anticardiolipin antibodies were associated with stillbirth (5.0% compared with 1.0%; OR 5.30, 95% CI, 2.39-11.76; IgG anti-β2-glycoprotein-I antibodies (1.9% compared with 0.6%) had an OR of 3.00 (95% CI 1.01-8.90) and IgM anticardiolipin antibodies (6.0% compared with 3.0%) had an OR of 2.03 (95% CI 1.09-3.76). Elevated levels of anticardiolipin and anti-β2- glycoprotein-I antibodies were associated with a threefold to fivefold increased odds of stillbirth. CONCLUSIONS:: Our data support consideration of testing for antiphospholipid antibodies in cases of otherwise unexplained stillbirth.

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