Antiphospholipid antibodies and stroke in young women

Robin L Brey, Christian Stallworth, David L. McGlasson, Marcella A. Wozniak, Robert J. Wityk, Barney J. Stern, Michael A. Sloan, Roger Sherwin, Thomas R. Price, Richard F. Macko, Constance J. Johnson, Christopher J. Earley, David W. Buchholz, J. Richard Hebel, Steven J. Kittner

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background and Purpose - Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies. Methods - We performed a population-based case-control study examining antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulants) using stored frozen sera and plasma in 160 cases and 340 controls enrolled in the Stroke Prevention in Young Women study. We evaluated for the presence of anticardiolipin antibody (IgG, IgM, and IgA isotypes) by an enzyme-linked immunosorbent assay and for the lupus anticoagulant using several phospholipid-dependent coagulation tests (activated partial thromboplastin time, dilute Russell's viper venom time) with mixing studies. If mixing studies were prolonged, confirmatory tests were performed. Results - A positive anticardiolipin antibody level of any isotype was seen in 43 cases (26.9%) and 62 controls (18.2%) (P=0.03), lupus anticoagulant in 29 cases (20.9%) and 38 controls (12.8%) (P=0.03), and either anticardiolipin antibody or lupus anticoagulant in 61 cases (42.1%) and 86 controls (27.9%) (P=0.003). After adjustment for age, current cigarette smoking, hypertension, diabetes, angina, ethnicity, body mass index, and high-density lipoprotein levels, the relative odds of stroke for women with anticardiolipin antibody immunoreactivity of any isotype or a lupus anticoagulant was 1.87 (95% confidence interval, 1.24 to 2.83; P=0.0027). Conclusions - The results from this study support the importance of antiphospholipid antibodies as an independent risk factor for stroke in young women.

Original languageEnglish (US)
Pages (from-to)2396-2400
Number of pages5
JournalStroke
Volume33
Issue number10
DOIs
StatePublished - Oct 1 2002

Fingerprint

Lupus Coagulation Inhibitor
Anticardiolipin Antibodies
Antiphospholipid Antibodies
Stroke
Partial Thromboplastin Time
Prothrombin Time
HDL Lipoproteins
Immunoglobulin A
Immunoglobulin M
Case-Control Studies
Phospholipids
Body Mass Index
Immunoglobulin G
Smoking
Enzyme-Linked Immunosorbent Assay
Odds Ratio
Confidence Intervals
Hypertension
Serum
Population

Keywords

  • Antibodies, antiphospholipid
  • Anticoagulants, lupus
  • Cerebrovascular disorders
  • Thrombosis
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Brey, R. L., Stallworth, C., McGlasson, D. L., Wozniak, M. A., Wityk, R. J., Stern, B. J., ... Kittner, S. J. (2002). Antiphospholipid antibodies and stroke in young women. Stroke, 33(10), 2396-2400. https://doi.org/10.1161/01.STR.0000031927.25510.D1

Antiphospholipid antibodies and stroke in young women. / Brey, Robin L; Stallworth, Christian; McGlasson, David L.; Wozniak, Marcella A.; Wityk, Robert J.; Stern, Barney J.; Sloan, Michael A.; Sherwin, Roger; Price, Thomas R.; Macko, Richard F.; Johnson, Constance J.; Earley, Christopher J.; Buchholz, David W.; Hebel, J. Richard; Kittner, Steven J.

In: Stroke, Vol. 33, No. 10, 01.10.2002, p. 2396-2400.

Research output: Contribution to journalArticle

Brey, RL, Stallworth, C, McGlasson, DL, Wozniak, MA, Wityk, RJ, Stern, BJ, Sloan, MA, Sherwin, R, Price, TR, Macko, RF, Johnson, CJ, Earley, CJ, Buchholz, DW, Hebel, JR & Kittner, SJ 2002, 'Antiphospholipid antibodies and stroke in young women', Stroke, vol. 33, no. 10, pp. 2396-2400. https://doi.org/10.1161/01.STR.0000031927.25510.D1
Brey RL, Stallworth C, McGlasson DL, Wozniak MA, Wityk RJ, Stern BJ et al. Antiphospholipid antibodies and stroke in young women. Stroke. 2002 Oct 1;33(10):2396-2400. https://doi.org/10.1161/01.STR.0000031927.25510.D1
Brey, Robin L ; Stallworth, Christian ; McGlasson, David L. ; Wozniak, Marcella A. ; Wityk, Robert J. ; Stern, Barney J. ; Sloan, Michael A. ; Sherwin, Roger ; Price, Thomas R. ; Macko, Richard F. ; Johnson, Constance J. ; Earley, Christopher J. ; Buchholz, David W. ; Hebel, J. Richard ; Kittner, Steven J. / Antiphospholipid antibodies and stroke in young women. In: Stroke. 2002 ; Vol. 33, No. 10. pp. 2396-2400.
@article{96d840158e55471cb3385776bbbeb1ff,
title = "Antiphospholipid antibodies and stroke in young women",
abstract = "Background and Purpose - Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies. Methods - We performed a population-based case-control study examining antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulants) using stored frozen sera and plasma in 160 cases and 340 controls enrolled in the Stroke Prevention in Young Women study. We evaluated for the presence of anticardiolipin antibody (IgG, IgM, and IgA isotypes) by an enzyme-linked immunosorbent assay and for the lupus anticoagulant using several phospholipid-dependent coagulation tests (activated partial thromboplastin time, dilute Russell's viper venom time) with mixing studies. If mixing studies were prolonged, confirmatory tests were performed. Results - A positive anticardiolipin antibody level of any isotype was seen in 43 cases (26.9{\%}) and 62 controls (18.2{\%}) (P=0.03), lupus anticoagulant in 29 cases (20.9{\%}) and 38 controls (12.8{\%}) (P=0.03), and either anticardiolipin antibody or lupus anticoagulant in 61 cases (42.1{\%}) and 86 controls (27.9{\%}) (P=0.003). After adjustment for age, current cigarette smoking, hypertension, diabetes, angina, ethnicity, body mass index, and high-density lipoprotein levels, the relative odds of stroke for women with anticardiolipin antibody immunoreactivity of any isotype or a lupus anticoagulant was 1.87 (95{\%} confidence interval, 1.24 to 2.83; P=0.0027). Conclusions - The results from this study support the importance of antiphospholipid antibodies as an independent risk factor for stroke in young women.",
keywords = "Antibodies, antiphospholipid, Anticoagulants, lupus, Cerebrovascular disorders, Thrombosis, Women",
author = "Brey, {Robin L} and Christian Stallworth and McGlasson, {David L.} and Wozniak, {Marcella A.} and Wityk, {Robert J.} and Stern, {Barney J.} and Sloan, {Michael A.} and Roger Sherwin and Price, {Thomas R.} and Macko, {Richard F.} and Johnson, {Constance J.} and Earley, {Christopher J.} and Buchholz, {David W.} and Hebel, {J. Richard} and Kittner, {Steven J.}",
year = "2002",
month = "10",
day = "1",
doi = "10.1161/01.STR.0000031927.25510.D1",
language = "English (US)",
volume = "33",
pages = "2396--2400",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Antiphospholipid antibodies and stroke in young women

AU - Brey, Robin L

AU - Stallworth, Christian

AU - McGlasson, David L.

AU - Wozniak, Marcella A.

AU - Wityk, Robert J.

AU - Stern, Barney J.

AU - Sloan, Michael A.

AU - Sherwin, Roger

AU - Price, Thomas R.

AU - Macko, Richard F.

AU - Johnson, Constance J.

AU - Earley, Christopher J.

AU - Buchholz, David W.

AU - Hebel, J. Richard

AU - Kittner, Steven J.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Background and Purpose - Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies. Methods - We performed a population-based case-control study examining antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulants) using stored frozen sera and plasma in 160 cases and 340 controls enrolled in the Stroke Prevention in Young Women study. We evaluated for the presence of anticardiolipin antibody (IgG, IgM, and IgA isotypes) by an enzyme-linked immunosorbent assay and for the lupus anticoagulant using several phospholipid-dependent coagulation tests (activated partial thromboplastin time, dilute Russell's viper venom time) with mixing studies. If mixing studies were prolonged, confirmatory tests were performed. Results - A positive anticardiolipin antibody level of any isotype was seen in 43 cases (26.9%) and 62 controls (18.2%) (P=0.03), lupus anticoagulant in 29 cases (20.9%) and 38 controls (12.8%) (P=0.03), and either anticardiolipin antibody or lupus anticoagulant in 61 cases (42.1%) and 86 controls (27.9%) (P=0.003). After adjustment for age, current cigarette smoking, hypertension, diabetes, angina, ethnicity, body mass index, and high-density lipoprotein levels, the relative odds of stroke for women with anticardiolipin antibody immunoreactivity of any isotype or a lupus anticoagulant was 1.87 (95% confidence interval, 1.24 to 2.83; P=0.0027). Conclusions - The results from this study support the importance of antiphospholipid antibodies as an independent risk factor for stroke in young women.

AB - Background and Purpose - Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies. Methods - We performed a population-based case-control study examining antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulants) using stored frozen sera and plasma in 160 cases and 340 controls enrolled in the Stroke Prevention in Young Women study. We evaluated for the presence of anticardiolipin antibody (IgG, IgM, and IgA isotypes) by an enzyme-linked immunosorbent assay and for the lupus anticoagulant using several phospholipid-dependent coagulation tests (activated partial thromboplastin time, dilute Russell's viper venom time) with mixing studies. If mixing studies were prolonged, confirmatory tests were performed. Results - A positive anticardiolipin antibody level of any isotype was seen in 43 cases (26.9%) and 62 controls (18.2%) (P=0.03), lupus anticoagulant in 29 cases (20.9%) and 38 controls (12.8%) (P=0.03), and either anticardiolipin antibody or lupus anticoagulant in 61 cases (42.1%) and 86 controls (27.9%) (P=0.003). After adjustment for age, current cigarette smoking, hypertension, diabetes, angina, ethnicity, body mass index, and high-density lipoprotein levels, the relative odds of stroke for women with anticardiolipin antibody immunoreactivity of any isotype or a lupus anticoagulant was 1.87 (95% confidence interval, 1.24 to 2.83; P=0.0027). Conclusions - The results from this study support the importance of antiphospholipid antibodies as an independent risk factor for stroke in young women.

KW - Antibodies, antiphospholipid

KW - Anticoagulants, lupus

KW - Cerebrovascular disorders

KW - Thrombosis

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=0036792784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036792784&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000031927.25510.D1

DO - 10.1161/01.STR.0000031927.25510.D1

M3 - Article

C2 - 12364727

AN - SCOPUS:0036792784

VL - 33

SP - 2396

EP - 2400

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 10

ER -