Antioxidant and hepatoprotective effects of Rosa damascena

C. R. Achuthan; B. H. Babu; Jose Padikkala

doi:10.1076/phbi.41.5.357.15945

Antioxidant and hepatoprotective effects of Rosa damascena

C. R. Achuthan, B. H. Babu, Jose Padikkala

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl₄. This indicated that R. damascena could protect against CCl ₄ induced hepatotoxicity, possibly by its free radical scavenging activity.

Original language	English (US)
Pages (from-to)	357-361
Number of pages	5
Journal	Pharmaceutical Biology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1076/phbi.41.5.357.15945
State	Published - Aug 2003
Externally published	Yes

Keywords

Alkaline phosphatase
Antioxidant
Glutamine oxaloacetate transaminase
Glutamine pyruvate transaminase
Hepatoprotection
Hydroxyl radical
Lipid peroxidation
Superoxide radical

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1076/phbi.41.5.357.15945

Cite this

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title = "Antioxidant and hepatoprotective effects of Rosa damascena",

abstract = "The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.",

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author = "Achuthan, {C. R.} and Babu, {B. H.} and Jose Padikkala",

year = "2003",

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AU - Babu, B. H.

AU - Padikkala, Jose

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N2 - The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.

AB - The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.

KW - Alkaline phosphatase

KW - Antioxidant

KW - Glutamine oxaloacetate transaminase

KW - Glutamine pyruvate transaminase

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KW - Hydroxyl radical

KW - Lipid peroxidation

KW - Superoxide radical

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Antioxidant and hepatoprotective effects of Rosa damascena

Abstract

Keywords

ASJC Scopus subject areas

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