Antioxidant and hepatoprotective effects of Rosa damascena

C. R. Achuthan, B. H. Babu, Jose Padikkala

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

The fresh juice of Rosa damascena Mill. flower exhibited promising in vitro antioxidant potential. The partially purified acetone fraction (AF) from silica gel column chromatography was found to be the active fraction with antioxidant properties. The AF required for 50% inhibition of superoxide radical production, hydroxyl radical generation and lipid peroxide formation were 13.75, 135 and 410μg/ml, respectively. Oral administration of AF at 50mg/kg body weight significantly reduced the serum alkaline phosphatase (ALP), glutamine pyruvate transaminase (GPT) and glutamine oxaloacetate transaminase (GOT) activity and lipid peroxide level in rats receiving an acute dose of CCl4. This indicated that R. damascena could protect against CCl 4 induced hepatotoxicity, possibly by its free radical scavenging activity.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalPharmaceutical Biology
Volume41
Issue number5
DOIs
StatePublished - Aug 2003
Externally publishedYes

Keywords

  • Alkaline phosphatase
  • Antioxidant
  • Glutamine oxaloacetate transaminase
  • Glutamine pyruvate transaminase
  • Hepatoprotection
  • Hydroxyl radical
  • Lipid peroxidation
  • Superoxide radical

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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