Antioxidant and hepatoprotective effect of Acanthus ilicifolius

B. H. Babu, B. S. Shylesh, J. Padikkala

Research output: Contribution to journalArticlepeer-review

245 Scopus citations

Abstract

The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC50 of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe2+/ascorbate system), 980 μg/ml (Fe3+/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalFitoterapia
Volume72
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Acanthus ilicifolius
  • Antihepatotoxic activity
  • Antioxidant activity
  • Oxygen-derived free radicals (ODFR)

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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