Antioxidant and hepatoprotective effect of Acanthus ilicifolius

B. H. Babu; B. S. Shylesh; J. Padikkala

doi:10.1016/S0367-326X(00)00300-2

Antioxidant and hepatoprotective effect of Acanthus ilicifolius

B. H. Babu, B. S. Shylesh, J. Padikkala

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC₅₀ of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe²⁺/ascorbate system), 980 μg/ml (Fe³⁺/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl₄ induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).

Original language	English (US)
Pages (from-to)	272-277
Number of pages	6
Journal	Fitoterapia
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/S0367-326X(00)00300-2
State	Published - 2001
Externally published	Yes

Keywords

Acanthus ilicifolius
Antihepatotoxic activity
Antioxidant activity
Oxygen-derived free radicals (ODFR)

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/S0367-326X(00)00300-2

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title = "Antioxidant and hepatoprotective effect of Acanthus ilicifolius",

abstract = "The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC50 of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe2+/ascorbate system), 980 μg/ml (Fe3+/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).",

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doi = "10.1016/S0367-326X(00)00300-2",

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AU - Babu, B. H.

AU - Shylesh, B. S.

AU - Padikkala, J.

PY - 2001

Y1 - 2001

N2 - The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC50 of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe2+/ascorbate system), 980 μg/ml (Fe3+/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).

AB - The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC50 of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe2+/ascorbate system), 980 μg/ml (Fe3+/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).

KW - Acanthus ilicifolius

KW - Antihepatotoxic activity

KW - Antioxidant activity

KW - Oxygen-derived free radicals (ODFR)

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Antioxidant and hepatoprotective effect of Acanthus ilicifolius

Abstract

Keywords

ASJC Scopus subject areas

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