Abstract
The alcoholic extract of Acanthus ilicifolius leaves inhibited the formation of oxygen derived free radicals (ODFR) in vitro with IC50 of 550 μg/ml, 2750 μg/ml, 670 μg/ml and 600 μg/ml (Fe2+/ascorbate system), 980 μg/ml (Fe3+/ADP/ascorbate system) for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation, respectively. The oral administration of the extract (250 and 500 mg/kg) significantly reduced CCl4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with those obtained with curcumin (100 mg/kg, p.o.).
Original language | English (US) |
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Pages (from-to) | 272-277 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 72 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Acanthus ilicifolius
- Antihepatotoxic activity
- Antioxidant activity
- Oxygen-derived free radicals (ODFR)
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology