Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration

Sergio A. Rosales-Corral, Russel J. Reiter, Dun Xian Tan, Lucien C. Manchester, Xiaoyan Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Oxidative stress is a constant feature in the pathogenic mechanisms of Alzheimer's disease. Free radical overproduction derived from different pathways in those areas where amyloid-beta forms aggregate pushes the balance between endogenous antioxidants and the homeostatic redox control toward a state of oxidative stress. Additionally, a vicious cycle between oxidative stress and neuroinflammation is formed, which further complicates the return to a physiologic balance. Even though amyloid-beta, by itself, may initiate a free radical chain reaction, free radicals in the Alzheimer's brain come mainly from the microglial respiratory burst and from damaged mitochondria (electron leakage). The majority of Alzheimer hypotheses - including the cholinergic hypothesis, the mitochondrial cascade, the calcium hypothesis, the insulin resistance hypothesis and the lipid connection - all include oxidative stress-related processes. The amyloid-beta processing is itself an oxidative stress-related process. Melatonin is a free radical scavenger which additionally modulates the neuroinflammatory response and may even directly interact with the amyloid-beta, preventing its aggregation. This chapter is devoted to the antioxidant and anti-inflammatory role of melatonin in Alzheimer's neurodegeneration.

Original languageEnglish (US)
Title of host publicationAging
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages177-193
Number of pages17
ISBN (Print)9780124059337
DOIs
StatePublished - Mar 2014

Keywords

  • Alzheimer's disease
  • Antioxidants
  • Free radical scavenger
  • Melatonin
  • Neurodegeneration
  • Oxidative stress

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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    Rosales-Corral, S. A., Reiter, R. J., Tan, D. X., Manchester, L. C., & Liu, X. (2014). Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. In Aging: Oxidative Stress and Dietary Antioxidants (pp. 177-193). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405933-7.00018-4