Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration

Sergio A. Rosales-Corral, Russel J Reiter, Dun Xian Tan, Lucien C. Manchester, Xiaoyan Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Oxidative stress is a constant feature in the pathogenic mechanisms of Alzheimer's disease. Free radical overproduction derived from different pathways in those areas where amyloid-beta forms aggregate pushes the balance between endogenous antioxidants and the homeostatic redox control toward a state of oxidative stress. Additionally, a vicious cycle between oxidative stress and neuroinflammation is formed, which further complicates the return to a physiologic balance. Even though amyloid-beta, by itself, may initiate a free radical chain reaction, free radicals in the Alzheimer's brain come mainly from the microglial respiratory burst and from damaged mitochondria (electron leakage). The majority of Alzheimer hypotheses - including the cholinergic hypothesis, the mitochondrial cascade, the calcium hypothesis, the insulin resistance hypothesis and the lipid connection - all include oxidative stress-related processes. The amyloid-beta processing is itself an oxidative stress-related process. Melatonin is a free radical scavenger which additionally modulates the neuroinflammatory response and may even directly interact with the amyloid-beta, preventing its aggregation. This chapter is devoted to the antioxidant and anti-inflammatory role of melatonin in Alzheimer's neurodegeneration.

Original languageEnglish (US)
Title of host publicationAging: Oxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Pages177-193
Number of pages17
ISBN (Print)9780124059337
DOIs
StatePublished - Mar 2014

Fingerprint

Melatonin
Oxidative Stress
Anti-Inflammatory Agents
Amyloid
Antioxidants
Free Radicals
Free Radical Scavengers
Respiratory Burst
Cholinergic Agents
Oxidation-Reduction
Insulin Resistance
Alzheimer Disease
Mitochondria
Electrons
Calcium
Lipids
Brain

Keywords

  • Alzheimer's disease
  • Antioxidants
  • Free radical scavenger
  • Melatonin
  • Neurodegeneration
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Rosales-Corral, S. A., Reiter, R. J., Tan, D. X., Manchester, L. C., & Liu, X. (2014). Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. In Aging: Oxidative Stress and Dietary Antioxidants (pp. 177-193). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405933-7.00018-4

Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. / Rosales-Corral, Sergio A.; Reiter, Russel J; Tan, Dun Xian; Manchester, Lucien C.; Liu, Xiaoyan.

Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. p. 177-193.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rosales-Corral, SA, Reiter, RJ, Tan, DX, Manchester, LC & Liu, X 2014, Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. in Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., pp. 177-193. https://doi.org/10.1016/B978-0-12-405933-7.00018-4
Rosales-Corral SA, Reiter RJ, Tan DX, Manchester LC, Liu X. Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. In Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc. 2014. p. 177-193 https://doi.org/10.1016/B978-0-12-405933-7.00018-4
Rosales-Corral, Sergio A. ; Reiter, Russel J ; Tan, Dun Xian ; Manchester, Lucien C. ; Liu, Xiaoyan. / Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration. Aging: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., 2014. pp. 177-193
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