Antioxidant and Anti-Inflammatory Role of Melatonin in Alzheimer's Neurodegeneration

Sergio A. Rosales-Corral, Russel J. Reiter, Dun-xian Tan, Lucien C. Manchester, Xiaoyan Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Oxidative stress is a constant feature in the pathogenic mechanisms of Alzheimer's disease. Free radical overproduction derived from different pathways in those areas where amyloid-beta forms aggregate pushes the balance between endogenous antioxidants and the homeostatic redox control toward a state of oxidative stress. Additionally, a vicious cycle between oxidative stress and neuroinflammation is formed, which further complicates the return to a physiologic balance. Even though amyloid-beta, by itself, may initiate a free radical chain reaction, free radicals in the Alzheimer's brain come mainly from the microglial respiratory burst and from damaged mitochondria (electron leakage). The majority of Alzheimer hypotheses - including the cholinergic hypothesis, the mitochondrial cascade, the calcium hypothesis, the insulin resistance hypothesis and the lipid connection - all include oxidative stress-related processes. The amyloid-beta processing is itself an oxidative stress-related process. Melatonin is a free radical scavenger which additionally modulates the neuroinflammatory response and may even directly interact with the amyloid-beta, preventing its aggregation. This chapter is devoted to the antioxidant and anti-inflammatory role of melatonin in Alzheimer's neurodegeneration.

Original languageEnglish (US)
Title of host publicationAging
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier Inc.
Number of pages17
ISBN (Print)9780124059337
StatePublished - Mar 2014


  • Alzheimer's disease
  • Antioxidants
  • Free radical scavenger
  • Melatonin
  • Neurodegeneration
  • Oxidative stress

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)


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