Antineoplastic diterpene-benzoate macrolides from the fijian red alga Callophycus serratus

Julia Kubanek, Anne C. Prusak, Terry W. Snell, Rachel A. Giese, Kenneth I. Hardcastle, Craig R. Fairchild, William Aalbersberg, Carmen Raventos-Suarez, Mark E. Hay

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

(Chemical Equation Presented) Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

Original languageEnglish (US)
Pages (from-to)5261-5264
Number of pages4
JournalOrganic Letters
Volume7
Issue number23
DOIs
StatePublished - Nov 10 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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