Abstract
A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
Original language | English (US) |
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Pages (from-to) | 541-543 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 59 |
Issue number | 5 |
DOIs | |
State | Published - May 1996 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry