Antiinflammatory C-glucosyl chromone from Aloe barbadensis

John A. Hutter; Mohammad Salman; William B. Stavinoha; Neera Satsangi; Robert F. Williams; Robert T. Streeper; Susan T. Weintraub

doi:10.1021/np9601519

Antiinflammatory C-glucosyl chromone from Aloe barbadensis

John A. Hutter, Mohammad Salman, William B. Stavinoha, Neera Satsangi, Robert F. Williams, Robert T. Streeper, Susan T. Weintraub

Biochemistry & Structural Biology

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

Original language	English (US)
Pages (from-to)	541-543
Number of pages	3
Journal	Journal of Natural Products
Volume	59
Issue number	5
DOIs	https://doi.org/10.1021/np9601519
State	Published - May 1 1996

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9601519

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title = "Antiinflammatory C-glucosyl chromone from Aloe barbadensis",

abstract = "A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.",

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AU - Hutter, John A.

AU - Salman, Mohammad

AU - Stavinoha, William B.

AU - Satsangi, Neera

AU - Williams, Robert F.

AU - Streeper, Robert T.

AU - Weintraub, Susan T.

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AB - A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

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