Antiinflammatory C-glucosyl chromone from Aloe barbadensis

John A. Hutter, Mohammad Salman, William B. Stavinoha, Neera Satsangi, Robert F. Williams, Robert T. Streeper, Susan E Weintraub

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number5
DOIs
StatePublished - May 1996

Fingerprint

Chromones
Aloe
Thymus
Aloe vera
Ear
Hydrocortisone
ears
Anti-Inflammatory Agents
Thymus Gland
cortisol
anti-inflammatory agents
Weights and Measures
dosage
anti-inflammatory activity
mice

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Hutter, J. A., Salman, M., Stavinoha, W. B., Satsangi, N., Williams, R. F., Streeper, R. T., & Weintraub, S. E. (1996). Antiinflammatory C-glucosyl chromone from Aloe barbadensis. Journal of Natural Products, 59(5), 541-543. https://doi.org/10.1021/np9601519

Antiinflammatory C-glucosyl chromone from Aloe barbadensis. / Hutter, John A.; Salman, Mohammad; Stavinoha, William B.; Satsangi, Neera; Williams, Robert F.; Streeper, Robert T.; Weintraub, Susan E.

In: Journal of Natural Products, Vol. 59, No. 5, 05.1996, p. 541-543.

Research output: Contribution to journalArticle

Hutter, JA, Salman, M, Stavinoha, WB, Satsangi, N, Williams, RF, Streeper, RT & Weintraub, SE 1996, 'Antiinflammatory C-glucosyl chromone from Aloe barbadensis', Journal of Natural Products, vol. 59, no. 5, pp. 541-543. https://doi.org/10.1021/np9601519
Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. Journal of Natural Products. 1996 May;59(5):541-543. https://doi.org/10.1021/np9601519
Hutter, John A. ; Salman, Mohammad ; Stavinoha, William B. ; Satsangi, Neera ; Williams, Robert F. ; Streeper, Robert T. ; Weintraub, Susan E. / Antiinflammatory C-glucosyl chromone from Aloe barbadensis. In: Journal of Natural Products. 1996 ; Vol. 59, No. 5. pp. 541-543.
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