Antiinflammatory C-glucosyl chromone from Aloe barbadensis

John A. Hutter, Mohammad Salman, William B. Stavinoha, Neera Satsangi, Robert F. Williams, Robert T. Streeper, Susan T. Weintraub

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number5
DOIs
StatePublished - May 1 1996

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Antiinflammatory C-glucosyl chromone from Aloe barbadensis'. Together they form a unique fingerprint.

Cite this