Abstract
A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-543 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1996 |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Antiinflammatory C-glucosyl chromone from Aloe barbadensis. / Hutter, John A.; Salman, Mohammad; Stavinoha, William B.; Satsangi, Neera; Williams, Robert F.; Streeper, Robert T.; Weintraub, Susan E.
In: Journal of Natural Products, Vol. 59, No. 5, 05.1996, p. 541-543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiinflammatory C-glucosyl chromone from Aloe barbadensis
AU - Hutter, John A.
AU - Salman, Mohammad
AU - Stavinoha, William B.
AU - Satsangi, Neera
AU - Williams, Robert F.
AU - Streeper, Robert T.
AU - Weintraub, Susan E
PY - 1996/5
Y1 - 1996/5
N2 - A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
AB - A new antiinflammatory agent identified as 8-[C-β-D-[2-O-(E)- cinnamoyl]glucopyranosyl]-2[(R)-2-hydroxypropyl]-7-methoxy-5- methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 μg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 μg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 μg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
UR - http://www.scopus.com/inward/record.url?scp=0029973175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029973175&partnerID=8YFLogxK
U2 - 10.1021/np9601519
DO - 10.1021/np9601519
M3 - Article
C2 - 8778246
AN - SCOPUS:0029973175
VL - 59
SP - 541
EP - 543
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 5
ER -