Antigenemia detected by radioimmunoassay in systemic aspergillosis

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Abstract

Because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an Aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. Antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillosis and in pleural fluid from an Aspergillus empyema but not in control sera or pleural fluid from 43 patients or 27 normal donors. When characterized with reference to onset of disease, antigenemia was an early sign of infection. This study shows the usefulness of the Aspergillus antigen radioimmunoassay for early, specific immunodiagnosis of systemic aspergillosis.

Original languageEnglish (US)
Pages (from-to)793-796
Number of pages4
JournalAnnals of internal medicine
Volume92
Issue number6
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Internal Medicine

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