Antifungal susceptibility testing of Exophiala spp. A head-to-head comparison of amphotericin B, itraconazole, posaconazole and voriconazole

Annette W. Fothergill, Michael G. Rinaldi, Deanna A. Sutton

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Frequently, diseases caused by black yeasts are chronic in nature with a high morbidity. In addition, these infections are often fatal and relapse is common, even after prolonged treatment. Although the CLSI Document M38-A outlines methods for antifungal susceptibility testing of moulds, Exophiala spp. are not directly discussed. In an effort to determine the antifungal susceptibility patterns of Exophiala spp. we tested 160 clinical isolates against amphotericin B, itraconazole, posaconazole, and voriconazole in a head-to-head comparison. Posaconazole and itraconazole were the most active in vitro with MICs falling well below the achievable serum levels typically observed with standard dosing regimens.

Original languageEnglish (US)
Pages (from-to)41-43
Number of pages3
JournalMedical mycology
Volume47
Issue number1
DOIs
StatePublished - Jan 9 2009

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Keywords

  • Antifungal susceptibility testing
  • CLSI methods
  • Exophiala species

ASJC Scopus subject areas

  • Infectious Diseases

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