Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans

George R. Thompson; Nathan P. Wiederhold; Annette W. Fothergill; Ana C. Vallor; Brian L. Wickes; Thomas F. Patterson

doi:10.1128/AAC.01216-08

Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans

George R. Thompson
, Nathan P. Wiederhold
, Annette W. Fothergill
, Ana C. Vallor
, Brian L. Wickes
, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

We measured antifungal activity against 128 cryptococcal isolates (86 of C. neoformans and 42 of C. gattii) to determine if differences in serotype susceptibility exist. Contrary to previous results, we found no serotype susceptibility differences. Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluconazole susceptibilities.

Original language	English (US)
Pages (from-to)	309-311
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	53
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01216-08
State	Published - Jan 2009

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We measured antifungal activity against 128 cryptococcal isolates (86 of C. neoformans and 42 of C. gattii) to determine if differences in serotype susceptibility exist. Contrary to previous results, we found no serotype susceptibility differences. Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluconazole susceptibilities.",

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AU - Wickes, Brian L.

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AB - We measured antifungal activity against 128 cryptococcal isolates (86 of C. neoformans and 42 of C. gattii) to determine if differences in serotype susceptibility exist. Contrary to previous results, we found no serotype susceptibility differences. Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluconazole susceptibilities.

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Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans

Abstract

ASJC Scopus subject areas

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