Abstract
Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of the most common systemic fungal infections for which antifungal resistance is a potential problem, the mechanisms of antifungal resistance, the correlation between in vitro susceptibility testing and clinical outcome, and the clinical implications of antifungal resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1073-1080 |
| Number of pages | 8 |
| Journal | Clinical Infectious Diseases |
| Volume | 35 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 1 2002 |
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ASJC Scopus subject areas
- Immunology
Cite this
Antifungal resistance in pathogenic fungi. / Perea, Sofia; Patterson, Thomas F.
In: Clinical Infectious Diseases, Vol. 35, No. 9, 01.11.2002, p. 1073-1080.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antifungal resistance in pathogenic fungi
AU - Perea, Sofia
AU - Patterson, Thomas F
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of the most common systemic fungal infections for which antifungal resistance is a potential problem, the mechanisms of antifungal resistance, the correlation between in vitro susceptibility testing and clinical outcome, and the clinical implications of antifungal resistance.
AB - Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of the most common systemic fungal infections for which antifungal resistance is a potential problem, the mechanisms of antifungal resistance, the correlation between in vitro susceptibility testing and clinical outcome, and the clinical implications of antifungal resistance.
UR - http://www.scopus.com/inward/record.url?scp=0036828026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036828026&partnerID=8YFLogxK
U2 - 10.1086/344058
DO - 10.1086/344058
M3 - Article
C2 - 12384841
AN - SCOPUS:0036828026
VL - 35
SP - 1073
EP - 1080
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -